@article{article_1424294, title={Diagnostic performance of whole blood viscosity indices in predicting the presence and severity of coronary artery disease}, journal={Journal of Medicine and Palliative Care}, volume={5}, pages={48–56}, year={2024}, DOI={10.47582/jompac.1424294}, author={Kıvrak, Ahmet and Yıldırım, Alp}, keywords={Blood viscosity, coronary artery disease, MAPH score, microcirculation, SYNTAX score}, abstract={Aims: Growing evidence suggests that blood viscosity plays a crucial role in both the development and acceleration of atherosclerosis. In this study, aimed to investigate the diagnostic performance of the mean platelet volume-age-total protein-hematocrit (MAPH) score, a new index for blood viscosity, in predicting the presence and severity of CAD in patients with suspected coronary artery disease (CAD). Methods: We retrospectively evaluated 431 patients who underwent coronary angiography. SYNTAX score (SS) were divided into 3 groups; low group ( <22), intermediate group (22-32) and, high group (≥32). Low (LSR) and and high (HSR) shear rates were derived using values of total protein and hematocrit. The MAPH score was calculated based on the threshold values of mean platelet volume, age, total protein, and hematocrit for predicting CAD. Results: The median LSR (60.7 vs. 43.1, p <0.001), mean HSR (17.3±1.3 vs. 16.2±1.2, p <0.001), and mean MAPH score (2.7±0.8 vs. 1.6±0.5, p <0.001) were higher in the CAD group compared to the non-CAD group. These indices of blood viscosity were found to be higher in the intermediate-high SS group compared to the low SS group. The threshold value of MAPH score for predicting CAD was >2 (sensitivity=78.2%, specificity=70.0%). It also had a graduated threshold value (>3, sensitivity=71.1%, specificity=62.5%) in distinguishing intermediate-high SS than low SS groups. In predicting both the presence and severity of CAD, the MAPH score exhibited superior diagnostic performance relative to the levels of LSR and HSR. Conclusion: In patients with suspected CAD, a gradual increase in the MAPH score demonstrated significant diagnostic performance in distinguishing both the presence and severity of CAD. In these patients, the MAPH score may serve as a potential screening tool and can be utilized for risk stratification.}, number={1}, publisher={MediHealth Academy Yayıncılık}