@article{article_1425883, title={Elucidating Ionization Behavior: Potentiometric Titration for Precise Determination of pKa Values in Medicinal Chemistry}, journal={Pharmata}, volume={4}, pages={46–50}, year={2024}, author={Ünal, Durişehvar and Aydoğdu, Safiye Nihal}, keywords={pKa values, potentiometric titration, medicinal chemistry, pharmacokinetics, drug discovery.}, abstract={The determination of pKa values holds paramount importance in the field of medicinal chemistry, serving as a critical parameter for understanding the ionization behavior of pharmaceutical compounds. This study employs potentiometric titration as a precise method to elucidate the pKa values of diverse molecules. The experimental methodology involved a carefully controlled titration setup, utilizing a pH meter to monitor the titration curve and identify inflection points corresponding to the dissociation of acidic or basic functional groups.}, number={2}, publisher={Ataturk University}