@article{article_1442667, title={Brain-Gut Network in Inflammatory Bowel Diseases and The Role of Vagal Nerve in Neuroinflammation}, journal={Yüksek İhtisas Üniversitesi Sağlık Bilimleri Dergisi}, volume={5}, pages={66–72}, year={2024}, author={Çalıkuşu, Ayşen and Gök Dağıdır, Hale and Bukan, Neslihan and Bahcelıoglu, Meltem}, keywords={Keywords: inflammatory bowel diseases, brain-gut axis, microbiota, neuroinflammation, neurodegeneration, vagal nerve stimulation}, abstract={In both normal and pathological situations, the brain and gut communicate. Intestinal inflammation is crucial in the progression of systemic inflammation and neuroinflammation. Inflammatory Bowel Diseases, neurodegeneration, and neuroinflammation all benefit from elucidating the molecular relationships between the gut and the brain. Crohn’s disease, ulcerative colitis, and indeterminate colitis are chronic disorders characterized by recurring episodes of gastrointestinal inflammation. Inflammatory bowel disease has evolved into a global disease in the 21st century, affecting around 6.8 million individuals and increasing in prevalence. According to growing evidence using clinical, epidemiological, and experimental data, Inflammatory Bowel Disease predisposes people to central nervous system disorders. The goal of this review is to address current knowledge in inflammatory bowel disorders, to analyze the interconnections between Inflammatory Bowel Diseases and neurodegenerative and neuroinflammatory diseases all along the gut-brain axis, and to emphasize the role of neuroinflammation in Inflammatory Bowel Diseases. Finally, we address vagal nerve stimulation as a potential treatment because it is a critical component of brain-gut interactions and exerts a dual anti-inflammatory role via its afferent and efferent fibers.}, number={2}, publisher={Yüksek İhtisas Üniversitesi}, organization={There is no supporting institution for this article.}