TY  - JOUR
T1  - Identification of TIG1 Associated Molecular Targets for Breast Cancer Using Bioinformatic Approach
TT  - Meme Kanserinde Biyoinformatik Yaklaşım Kullanılarak TIG1 ile İlişkili Moleküler Hedeflerin Belirlenmesi
AU  - Korak, Tuğcan
AU  - Bal Albayrak, Merve Gulsen
AU  - Akpınar, Gürler
AU  - Kasap, Murat
PY  - 2024
DA  - December
Y2  - 2024
DO  - 10.37989/gumussagbil.1459020
JF  - Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi
JO  - Gümüşhane Sağlık Bilimleri Dergisi
PB  - Gumushane University
WT  - DergiPark
SN  - 2146-9954
SP  - 1807
EP  - 1817
VL  - 13
IS  - 4
LA  - en
AB  - e-posta/e-mail:tugcankorak@gmail.com/tugcan.korak@kocaeli.edu.trKabul Tarihi/Accepted:Tazarotene-induced gene 1 (TIG1) is involved in modulating the α-tubulin modification and effectively inhibiting tumor growth. In this bioinformatics study, we aim to propose novel therapeutic targets in breast cancer by utilizing differentially expressed genes (DEGs) of TIG1 in inflammatory breast cancer (IBC) and examining their correlation with the molecular and immune subtypes. Using the GEO2R tool, we analyzed DEGs in the GSE30543 dataset, specifically comparing suppressed TIG1 groups with control samples from SUM149 cells. Functional annotation analysis of DEGs were explored using SRplot with data from STRING (|log2(FC)| >2 and p
KW  - Biomarker
KW  - Breast cancer
KW  - GEO
KW  - TIG1
N2  - Tazaroten-indüklü gen 1 (TIG1), α-tubulin tirosinasyon döngüsünü modüle etmek ve tümör büyümesini etkili bir şekilde inhibe etmekle ilişkilidir. Bu biyoinformatik çalışmada, TIG1’in inflamatuar meme kanserindeki (IBC) farklı olarak ifade edilen genlerinin (DEG’ler) moleküler ve immün alt tiplerle olan korelasyonlarını inceleyerek meme kanserinde yeni terapötik hedefler önermeyi amaçlamaktayız. GEO2R aracını kullanarak, GSE30543 veri setindeki DEG’ler analiz edildi ve özellikle baskılanmış TIG1 grupları SUM149 hücrelerinden kontrol örnekleriyle karşılaştırıldı. DEG’lerin fonksiyonel annotasyon analizi, SRplot aracılığıyla STRING verileri (|log2(FC)| >2 ve p
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UR  - https://doi.org/10.37989/gumussagbil.1459020
L1  - https://dergipark.org.tr/en/download/article-file/3822492
ER  -