TY - JOUR T1 - MEFV VE HLA-B27 GEN ANALİZİNİN MEAN PLATELET VOLÜM DÜZEYLERİ İLE İLİŞKİSİ TT - THE RELATIONSHIP OF MEAN PLATELET VOLUME LEVELS WITH MEFV AND HLA-B27 GENE ANALYSIS AU - Ünal, Kübranur PY - 2016 DA - March JF - Turkish Medical Journal JO - TMJ PB - Ankara Yıldırım Beyazıt Üniversitesi Yenimahalle Eğitim ve Araştırma Hastanesi WT - DergiPark SN - 3023-8196 SP - 8 EP - 15 VL - 8 IS - 1 LA - tr AB - Amaç: Dolaşımdaki platelet boyutunun (MPV) sistemik inflamasyon şiddeti ile iliş-kili olduğu ileri sürülmektedir. Bu çalışmada amacımız, MEFV (MEditerranean FeVer) ve HLA-B27 gen analizi sonuçlarından yola çıkarak MPV değerlerinin anlamlı değişiklik gösterip göstermediğini ortaya çıkarmaktır.Materyal ve Metot: Ailevi Akdeniz Ateşi (FMF) ve spondiloartropati (SpA) ön tanısı alan, birbirinden bağımsız iki hasta kümesi üzerinde değerlendirme yapılmıştır. Ayırıcı tanılarını yapmak ve kesin tanılarına ulaşmak amacı ile MEFV mutasyon analizi (n: 126) ve HLA-B27 gen analizi (n: 112) istemi olan hastalar çalışmaya dahil edildi. Hastaların yaş, cinsiyet, MEFV gen mutasyon analizi, HLA-B27 gen analizi, C reaktif protein (CRP), eritrosit sedimentasyon hızı (ESR ), platelet sayısı (PLT), mean platelet volüm(MPV), platokrit (PCT) ve platelet dağılım genişliği (PDW) değerleri kaydedildi. CRP değerleri dikkate alınarak iki farklı hasta kümesi kendi arasında üç gruba ayrıldı. CRP değerleri > 5 mg/L olan gen analizi pozitif olan akut atak dönemindeki hastalar (grup 1), CRP değerleri KW - MEFV KW - HLA-B27 KW - MPV N2 - Objectives: The size of platelets (MPV) in circulation is suggested to be associated with the intensity of systemic inflammation. The aim of the study was to investigate MPV influences in the patients who underwent a genetic test for MEFV and HLA-B27.Materials and Methods: The patients who have a suspicion of Familial Mediterranean Fever (FMF) or spondyloarthropathy and underwent a genetic test for MEFV mutation (n: 126) or HLA-B27 genetic test (n: 112) were included in the study. MEFV mutation, HLA-B27 gene analysis, levels of C reactive protein (CRP), erythrocyte sedimentation rate (ESR), platelet count (PLT), platelet distribution width (PDW), platocrit (PLT), mean platelet volume (MPV) and demographic data of the patients were noted. The patients were divided into three groups according to the CRP results. Group 1: CRP > 5 mg/L MEFV positive (n: 35) or HLA-B27 (n: 53) positive. Group 2: CRP CR - 1. Kaushansky K. The molecular mechanisms that control thrombopoiesis. J Clin Invest 2005;115:3339-47. CR - 2. Thompson CB, Eaton KA, Princiotta SM, Rushin CA, Valeri CR. 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Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Current Pharmaceutical Design 2011;17:47-58. UR - https://dergipark.org.tr/en/pub/tmj/article/1463458 L1 - https://dergipark.org.tr/en/download/article-file/3840656 ER -