TY  - JOUR
T1  - Investigation of stability and activity of quaternized zinc phthalocyanine photosensitizer with fused extended conjugation in vitro conditions
AU  - Şakar, Dolunay
AU  - Karahan, Yeşim
AU  - Gümrükçü Köse, Gülşah
AU  - Keser Karaoğlan, Gülnur
PY  - 2024
DA  - April
JF  - Sigma Journal of Engineering and Natural Sciences
JO  - SIGMA
PB  - Yildiz Technical University
WT  - DergiPark
SN  - 1304-7191
SP  - 490
EP  - 496
VL  - 42
IS  - 2
LA  - en
AB  - Quaternized zinc phthalocyanine (QZnPc) which is water soluable is a promising candidate for photo dynamic therapy (PDT) applications. The physicochemical properties like the stability, activity, particle size, surface charge of tetrakis-(4-[(1E)-3-iminoprop-1-en-1-yl]-N,N,N-trimethylphenylammonium) phthalocyaninato zinc(II)] tetraiodide (II) quaternized zinc phthalocyanine (fused extended conjugation, QZnPc-FE) were investigated. The Zeta Potential Analyzer was used for this purpose. QZnPc-FE is freshly synthesized, water soluble quaternized zinc phthalocyanine and used as potential photosensitizer for PDT application. The stability and activity behavior of QZnPc-FE was determined in vitro conditions such as different pHs and in simulated body fluids as function of time via Zetasizer measurements and UV/VIS absorbances, respectively. Morphology of the QZnPc-FE was determined via XRD and the organic solvent effect with different polarity on QZnPc-FE was checked by UV/VIS. The optimum stability and activity conditions of QZnPc-FE in vitro conditions were deter-mined, and the obtained results showed that the studied compound can be used for medical (PDT) and pharmaceutical applications.
KW  - Water Soluable Quaternized
Zinc Phthalocyanine
KW  - Zeta
Potential
KW  - Particle Size
KW  - Stability
KW  - Particle Charge; Activity
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UR  - https://dergipark.org.tr/en/pub/sigma/issue//1465900
L1  - https://dergipark.org.tr/en/download/article-file/3851606
ER  -