TY  - JOUR
T1  - Multidisciplinary Management of Hepatoblastoma: Three Years of Experience at a Single Centre
AU  - Arslantaş, Esra
AU  - Ayçiçek, Ali
AU  - Akpınar Tekgündüz, Sibel
AU  - Ertürk, Saide
AU  - Akyel, Nazlı Gülsüm
AU  - Yılmaz Özgüven, Banu
AU  - Kınacı, Erdem
AU  - Özden, İlgin
PY  - 2024
DA  - August
Y2  - 2024
DO  - 10.26650/jchild.2024.1477676
JF  - Çocuk Dergisi
PB  - Istanbul University
WT  - DergiPark
SN  - 1308-8491
SP  - 70
EP  - 77
VL  - 24
IS  - 2
LA  - en
AB  - Objective: The aim of this study was to report the short-term outcomes of paediatric hepatoblastoma managed by hepatobiliary surgery and paediatric oncology from a single centre.Methods: Children with hepatoblastoma diagnosed between May 2020 and February 2023 and treated comprehensively in a single centre, were retrospectively reviewed. Management was multidisciplinary and followed the SIOPEL protocols (SIOPEL III-IV).Results: Eight paediatric patients with a median (range) age at diagnosis of 24 (5-68) months were included. The most common complaint was abdominal distension. There were no patients with PRETEXT stage I. Patients were graded as stage II (n=4), stage III (n=2), and stage IV (n=2). Half of the patients were classified in the standard risk group and the other half in the high-risk group. Chemotherapy was initiated in seven patients, and one was transferred directly to surgery for overt rupture. After neoadjuvant chemotherapy, complete response (CR) was not achieved in any patient, partial response (PR) was achieved in half (n=4), progressive disease and stable disease were present in one patient each, and one patient died. Four patients underwent radical hepatectomy with negative surgical margins after chemotherapy. The median (range) follow-up period was 18 (2-47) months. No recurrence was observed in any patient during follow-up, and the overall and event-free survival rates were 88% and 75%, respectively.Conclusions: The collective work of surgery and paediatric oncology in management is essential to achieve optimal results.
KW  - Hepatoblastoma
KW  - children
KW  - hepatectomy
KW  - chemotherapy
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UR  - https://doi.org/10.26650/jchild.2024.1477676
L1  - https://dergipark.org.tr/en/download/article-file/3902499
ER  -