TY - JOUR T1 - Characteristics of Patients with Craniopharyngioma and LongTerm Outcomes of Treatment AU - Hacişahinoğulları, Hülya AU - Bilik Oyman, Gamze AU - Dölen, Duygu AU - Bilgiç, M Bilge AU - Meral, Rasim AU - Yalın, Gulsah AU - Gül, Nurdan AU - Kubat Uzum, Ayşe AU - Soyluk Selçukbiricik, Özlem PY - 2024 DA - June Y2 - 2024 DO - 10.26650/Tr-ENT.2024.1479029 JF - The Turkish Journal of Ear Nose and Throat JO - Tr-ENT PB - Istanbul University WT - DergiPark SN - 2602-4837 SP - 60 EP - 65 VL - 34 IS - 2 LA - en AB - Objective: Craniopharyngioma (CP) is benign, but its treatment is challenging because of its occurrence in a critical area. Hypothalamic-pituitary dysfunction (HPD) is an important complication that is related to tumour itself or to therapy. This study identified the long-term outcomes of CPs.Material and Methods: Records of 44 patients with CPs followed up at the Istanbul Faculty of Medicine were retrospectively reviewed.Results: The mean age of 34 patients (M/F: 19/15) at diagnosis was 24±13.3 years. The most common symptoms were headache (60.3%) and visual impairment (45.5%). The tumour was localised in suprasellar region in 76.6%, in sellar-suprasellar in 16.7%, and in the sellar region in 6.7% of the patients. The mean tumour diameter was 32.7±10.4 mm (n: 19). Surgery was the first line of treatment in all patients except one, and 13 patients underwent more than one operation. Ten patients received radiotherapy. The median duration of follow-up was 6.5 years. Anterior pituitary dysfunction was observed in all patients: hypocortisolism in 88.2%, hypothyroidism in 97%, hypogonadism in 88.2%, growth hormone deficiency in 68.2%, and prolactin deficiency in 20.6% of the patients. Diabetes insipidus occurred in 97% of the patients. Recurrence developed in 2 patients (after 5-6 years). At the end of all treatments, 15 patients had residual disease.Conclusion: The curative treatment of CP is surgery. HPD is associated with increased mortality and morbidity and decreased quality of life. It is essential to protect the hipothalamo-pituitary axis and to choose the best treatment option for each patient. KW - Craniopharyngioma KW - hormone KW - pituitary KW - hormone deficiency KW - hypothalamus CR - 1. Parisi JE, Mena H. Nonglial tumours. In: Principles and Practice of Neuropathology. Mosby, St. Louis: Oxford University Press 1993: p.203-66. google scholar CR - 2. Ostrom QT, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS. CBTRUS statistical report: Primary brain and other central nervous system tumors diagnosed in the United States in 2014-2018. Neuro Oncol 2021;23:iii1-105. google scholar CR - 3. 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