TY  - JOUR
T1  - Investigation of dual AChE/MAO inhibitory activities of new morpholine and piperazine structured compounds
AU  - Kurban, Berkant
AU  - Osmaniye, Derya
AU  - Sağlık Özkan, Begüm Nurpelin
AU  - Kaplancıklı, Zafer Asım
PY  - 2024
DA  - August
Y2  - 2024
DO  - 10.55971/EJLS.1497639
JF  - European Journal of Life Sciences
JO  - Eur J Life Sci
PB  - Anadolu University
WT  - DergiPark
SN  - 2822-5333
SP  - 55
EP  - 65
VL  - 3
IS  - 2
LA  - en
AB  - In this study, a series of new compounds containing piperazine and morpholine rings were synthesized. Characterization studies of the obtained compounds were carried out with the help of HRMS, 1H-NMR and 13C-NMR spectroscopic methods. Acetylcholinesterase (AChE) / Monoamine oxidase B (MAO-B) inhibitory potentials of the compounds were investigated using in silico and in vitro methods. Compound 3a was the compound with the highest inhibitory potential against AChE and MAO-B enzymes, with IC50=0.065±0.002 µM and IC50=0.072±0.003 µM values, respectively. Compounds 3a and 3b interacted with crucial amino acid residues of the hMAO-B (PDB ID: 2V5Z) and AChE (PDB ID: 4EY7) enzymes in the docking studies. Compounds 3a and 3b had the highest affinity for the AChE and MAO-B enzymes.
KW  - AChE
KW  - MAO-B
KW  - Piperazine
KW  - Morpholine
KW  - Docking
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UR  - https://doi.org/10.55971/EJLS.1497639
L1  - https://dergipark.org.tr/en/download/article-file/3990036
ER  -