TY - JOUR T1 - Remineralization Potential of Ginger-Honey on Initial Enamel Lesions of Different Depth TT - Zencefil-Balın Farklı Derinlikteki Başlangıç Mine Lezyonlarında Remineralizasyon Potansiyeli AU - Çelik, Zeynep Ceren AU - Turkmen, Esma AU - Tağtekin, Dilek AU - Yanıkoğlu, Funda PY - 2025 DA - April Y2 - 2024 DO - 10.15311/selcukdentj.1499934 JF - Selcuk Dental Journal JO - Selcuk Dent J PB - Selcuk University WT - DergiPark SN - 2148-7529 SP - 80 EP - 87 VL - 12 IS - 1 LA - en AB - Aim: The present study aims to determine the remineralization efficacy of toothpaste with the active ingredients of ginger and honey on in-vitro produced early dental caries lesions by using ultrasound, fluorescence, surface microhardness and light and scanning electron microscope methods.Methods: Total of 105 enamel samplesin total were divided into three main groups which were exposed to a demineralizing solution for 18 (D1), 36 (D2), and 72 (D3) hours to take initial measurements by ultrasound, fluorescence, and surface microhardness, SEM. All main groups were divided into three subgroups each then, topically applied a toothpaste with NaF content (R1N) and a dental toothpaste with ginger-honey content (R1G) (Gumgumix) by a toothbrush three times a day for five minutes and stored in remineralizing solution, measured at the end. The one-way ANOVA test was used to compare the continuous data.Results: Toothpaste with ginger-honey content produced significant remineralization results (p=0.033) on the 52-micron initial enamel lesions (D1) by microhardness. Similarly, the fluorescence size (p=0.001), microscope (p KW - Initial enamel lesion KW - remineralization KW - ultrasound KW - Fluoresence. N2 - Amaç: Bu çalışma, deneysel olarak oluşturulmuş başlangıç çürüklerinde etken maddesi zencefil ve bal olan diş macununun remineralizasyon etkinliğinin ultrason, FluoreCam yüzey mikrosertlik ölçüm metodlarıyla tespit edilmesini amaçlamıştır.Gereç ve Yöntemler: Toplam 105 adet mine örneği 3 anagruba ayrılarak 18(D1), 36 (D2) ve 72 saat demineralizasyon solüsyonu içerisinde bekletilerek başlangıç ölçümleri ultrason, Fluorecam ve yüzey mikrosertlik, SEM ölçümleri alınmış, tüm derinlik grupları 3’er gruba ayrılarak NaF içeren diş macunu (R1N) zencefil-bal içeren diş kremi (R1Z) (Gumgumix) günde 3 defa 5 dk boyunca diş fırçası yardımı ile topikal uygulanmış ve remineralizasyon solüsyonunda bekletilerek ölçümleri alınmıştır. Sürekli verilerin karşılaştırılmasında Tek yönlü ANOVA testi kullanılmıştır.Bulgular: Çalışmamızda da 53 mikronluk başlangıç mine lezyonlarında (D1) zencefil-bal içeren diş kremi anlamlı remineralizasyon değerleri vermiştir (p=0,033). Aynı şekilde 80 mikronluk lezyonun (D2) FluoreCam size, mikroskop ve mikrosertlik sonuçlarında da remineralizasyon bariz olarak gösterilmiştir (p=0,001, p CR - 1. Pitts NB, Zero DT, Marsh PD, et al. Dental caries. Nat Rev Dis Primers. 2017;3:17030. CR - 2. Akküç S, Duruk G, Keleş A. Remineralization effect of three different agents on initial caries and erosive lesions: a micro-computed tomography and scanning electron microscopy analysis. BMC Oral Health. 2023;23(1):106. CR - 3. Desai H, Stewart CA, Finer Y. Minimally invasive therapies for the management of dental caries: a literature review. Dent J (Basel). 2021;9(12):147. CR - 4. Cai F, Shen P, Walker GD, Reynolds C, Yuan Y, Reynolds EC. Remineralization of enamel subsurface lesions by chewing gum with added calcium. J Dent. 2009;37(11):763-768. CR - 5. Urquhart O, Tampi M, Pilcher L, et al. Nonrestorative treatments for caries: systematic review and network meta-analysis. J Dent Res. 2019;98(1):14-26. CR - 6. Lima RMT, Reis AC, Menezes AP, et al. Protective and therapeutic potential of ginger (Zingiber officinale) extract and [6]-gingerol in cancer: A comprehensive review. Phytother Res. 2018;1-23. CR - 7. Onyeagba R, Ugbogu O, Okeke C, Iroakasi O. Studies on the antimicrobial effects of garlic (Allium sativum Linn), ginger (Zingiber officinale Roscoe), and lime (Citrus aurantifolia Linn). Afr J Biotechnol. 2004;3(10):552-554. CR - 8. Arifa MK, Ephraim R, Rajamani T. Recent Advances in Dental Hard Tissue Remineralization: A Review of Literature. Int J Clin Pediatr Dent. 2019;12(2):139-144. CR - 9. Shekar BRC, Nagarajappa R, Suma S, Thakur R. Herbal extracts in oral healthcare: a review of the current scenario and its future needs. Pharmacogn Rev. 2015;9(18):87. CR - 10. Gimenez T., Piovesan C., Braga M.M., Raggio D.P., Deery C., Ricketts D.N., Ekstrand K.R., Mendes F.M. Visual Inspection for Caries Detection: A Systematic Review and Meta-analysis. J. Dent. Res. 2015;94:895–904. CR - 11. Schwendicke F., Tzschoppe M., Paris S. Radiographic caries detection: A systematic review and meta-analysis. J. Dent. 2015;43:924–933. CR - 12. Amaechi B, Higham S & Edgar W. Factors affecting the development of carious lesions in bovine teeth in vitro. Archives of Oral Biology. 1998;43, 619-628. CR - 13. Bilgin Göçmen, G, Yanikoğlu F, Tağtekin D, Stookey GK, Schemehorn BR, Hayran O. Remineralization Potential Of Different Agents And Assessment By A New Caries Detection Device. Dentistry: Advanced Research. 2016: 39-43. CR - 14. Kade KK, Chaudhary S, Shah R, Patil S, Patel A, Kamble A. Comparative evaluation of the remineralization potential of fluoride-containing toothpaste, honey ginger paste, and ozone: an in vitro study. Int J Clin Pediatr Dent. 2022;15(5):541-548. CR - 15. Shaker M, Jamil WE, El Sharkawy DA. Effectiveness of ginger-honey mixture and rosemary on remineralization and prevention of enamel white spot lesions measured by color change. Alazhar Dent J Girls. 2022;9(3):391-398. CR - 16. Shah N, Bansal N, Logani A. Recent advances in imaging technologies in dentistry. World J Radiol. 2014;6:794-807. CR - 17. Çalışkan Yanıkoğlu F, Öztürk F, Hayran O, Analoui M, Stookey G. Detection of natural white spot caries lesions by an ultrasonic system. Caries Res. 2000;34(3):225-232. CR - 18. Bozkurt FÖ, Tagtekin D, Yanikoglu F, Fontana M, Gonzalez-Cabeza C, Stookey GK. Capability of an ultrasonic system to detect very early caries. Marmara Dental Journal. 2013;1:16-19. CR - 19. Bab I, Feuerstein O, Gazit D. Ultrasonic detector of proximal caries. Caries Res. 1997;31(4):322. CR - 20. Kim J, Shin TJ, Kong HJ, Hwang JY, Hyun HK. High-Frequency Ultrasound Imaging for Examination of Early Dental Caries. J Dent Res. 2019;98(3):363-367. CR - 21. Gocmen GB, Yanikoglu F, Tagtekin D, Stookey GK, Schemehorn BR, Hayran O. Effectiveness of some herbals on initial enamel caries lesion. Asian Pac J Trop Biomed. 2016;6(10):846-850. CR - 22. Talwar M, Borzabadi-Farahani A, Lynch E, Borsboom P, Ruben J. Remineralization of Demineralized Enamel and Dentine Using 3 Dentifrices-An InVitro Study. Dent J (Basel). 2019; 7(3):91. CR - 23. Diniz MB, Eckert GJ, González Cabezas C, Cordeiro RDCL, Ferreira-Zandona AG. Caries detection around restorations using ICDAS and optical devices. J Esthet Restor Dent. 2016;28(2):110-121. CR - 24. Abufarwa M, Noureldin A, Campbell PM, Buschang PH. Reliability and validity of FluoreCam for white-spot lesion detection: an in vitro study. J Investig Clin Dent. 2018;9(1). CR - 25. Korkut B, Yanikoglu F, Tagtekin D. In vitro assessment of dimensional alterations of worn human incisors. PARIPEX-Indian J Res. 2016;4. CR - 26. Celik ZC, Yavlal GO, Yanıkoglu F, Kargul B, Tagtekin D, Stookey GK, Peker S, Hayran O. Do Ginger Extract, Natural Honey and Bitter Chocolate Remineralize Enamel Surface as Fluoride Toothpastes? An In-Vitro Study. Niger J Clin Pract. 2021;24(9):1283-1288. UR - https://doi.org/10.15311/selcukdentj.1499934 L1 - https://dergipark.org.tr/en/download/article-file/4000144 ER -