TY  - JOUR
T1  - The relationship between lipid levels and clinical outcomes in sepsis patients in the intensive care unit: a retrospective study
AU  - Kollu, Korhan
AU  - Kızılarslanoğlu, Muhammet Cemal
PY  - 2024
DA  - October
Y2  - 2024
DO  - 10.32322/jhsm.1507962
JF  - Journal of Health Sciences and Medicine
JO  - J Health Sci Med /JHSM /jhsm
PB  - MediHealth Academy Yayıncılık
WT  - DergiPark
SN  - 2636-8579
SP  - 615
EP  - 620
VL  - 7
IS  - 6
LA  - en
AB  - Aims: This study aimed to investigate the relationship between serum cholesterol levels (HDL-C, LDL-C, and triglycerides) and clinical outcomes in sepsis patients in an intensive care unit (ICU).Methods: This retrospective study included patients aged >18 years diagnosed with sepsis who were admitted to the Internal Medicine ICUs of Konya City Hospital between June 15, 2021, and March 6, 2024. All data were obtained from routine blood tests of the patients in the ICU.Results: The study included 477 patients (median age, 73 years; females, 45.9%). The median levels of APACHE-II and SOFA scores were 27 (range, 5-55) and 7 (range, 2-19) points, respectively. The survived patients were younger and had lower median APACHE and SOFA scores compared to the non-survived patients (p
KW  - Sepsis
KW  - lipid levels
KW  - intensive care unit
KW  - lipid metabolism
KW  - prognosis
KW  - critically ill
CR  - Kim JY, Lee EY, Park JK, Song YW, Kim JR, Cho KH. Patients with rheumatoid arthritis show altered lipoprotein profiles with dysfunctional high-density lipoproteins that can exacerbate inflammatory and atherogenic process. PLoS One. 2016;11(10): e0164564.
CR  - Robertson KA, Ghazal P. Interferon control of the sterol metabolic network: bidirectional molecular circuitry-mediating host protection. Front Immunol. 2016;7:634.
CR  - Yao Z, Mates JM, Cheplowitz AM, et al. Blood-borne lipopolysaccharide is rapidly eliminated by liver sinusoidal endothelial cells via high-density lipoprotein. J Immunol. 2016; 197(6):2390-2399.
CR  - Surbatovic M, Popovic N, Vojvodic D, et al. Cytokine profile in severe gram-positive and gram-negative abdominal sepsis. Sci Rep. 2015;5:11355.
CR  - Damas P, Ledoux D, Nys M, et al. Cytokine serum level during severe sepsis in human IL-6 as a marker of severity. Ann Surg. 1992;215(4):356-362.
CR  - Lekkou A, Mouzaki A, Siagris D, Ravani I, Gogos CA. Serum lipid profile, cytokine production, and clinical outcome in patients with severe sepsis. J Crit Care. 2014;29(5):723-727.
CR  - Fraunberger P, Pilz G, Cremer P, Werdan K, Walli AK. Association of serum tumor necrosis factor levels with decrease of cholesterol during septic shock. Shock. 1998;10(5):359-363.
CR  - Barlage S, Gnewuch C, Liebisch G, et al. Changes in HDL-associated apolipoproteins relate to mortality in human sepsis and correlate to monocyte and platelet activation. Int Care Med. 2009;35(11):1877-1885.
CR  - Memiş D, Gursoy O, Tasdogan M, et al. High C-reactive protein and low cholesterol levels are prognostic markers of survival in severe sepsis. J Clin Anesth. 2007;19(3):186-191.
CR  - Liu SH, Liang HY, Li HY, Ding XF, Sun TW, Wang J. Effect of low high-density lipoprotein levels on mortality of septic patients: a systematic review and meta-analysis of cohort studies. World J Emerg Med. 2020;11(2):109-116.
CR  - Hofmaenner DA, Arina P, Kleyman A, et al. Association between hypocholesterolemia and mortality in critically ill patients with sepsis: a systematic review and meta-analysis. Crit Care Explor. 2023;5(2):e0860.
CR  - Seymour CW, Liu VX, Iwashyna TJ, et al. Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (Sepsis-3). Jama. 2016; 315(8):762-774.
CR  - Taylor R, Zhang C, George D, et al. Low circulatory levels of total cholesterol, HDL-C and LDL-C are associated with death of patients with sepsis and critical illness: systematic review, meta-analysis, and perspective of observational studies. EBioMedicine. 2024;100:104981.
CR  - Chien JY, Jerng JS, Yu CJ, Yang PC. Low serum level of high-density lipoprotein cholesterol is a poor prognostic factor for severe sepsis. Crit Care Med. 2005;33(8):1688-1693.
CR  - van Leeuwen HJ, Heezius EC, Dallinga GM, van Strijp JA, Verhoef J, van Kessel KP. Lipoprotein metabolism in patients with severe sepsis. Crit Care Med. 2003;31(5):1359-1366.
CR  - Maile MD, Sigakis MJ, Stringer KA, Jewell ES, Engoren MC. Impact of the pre-illness lipid profile on sepsis mortality. J Crit Care. 2020;57:197-202.
CR  - Aydemir S, & Hoşgün D. The role of serum lipoprotein levels in predicting independent short-term mortality in COVID-19 patients. Anat Curr Med J. 2022;4(2):162-166.
CR  - Guirgis FW, Dodani S, Leeuwenburgh C, et al. HDL inflammatory index correlates with and predicts severity of organ failure in patients with sepsis and septic shock. PLoS One. 2018;13(9):e0203813.
CR  - Tanaka S, Couret D, Tran-Dinh A, et al. High-density lipoproteins during sepsis: from bench to bedside. Crit Care. 2020;24(1):134.
CR  - Presterl E, Staudinger T, Pettermann M, et al. Cytokine profile and correlation to the APACHE III and MPM II scores in patients with sepsis. Am J Respir Crit Care Med. 1997;156(3 Pt 1):825-832.
CR  - Novak F, Borovska J, Vecka M, et al. Plasma phospholipid fatty acid profile is altered in both septic and non-septic critically ill: a correlation with inflammatory markers and albumin. Lipids. 2017;52(3):245-254.
CR  - Guo JY, Chou RH, Kuo CS, et al. The paradox of the glycemic gap: Does relative hypoglycemia exist in critically ill patients?. Clin Nutr. 2021;40(7):4654-4661.
CR  - Hofmaenner DA, Kleyman A, Press A, Bauer M, Singer M. The many roles of cholesterol in sepsis: a review. Am J Respir Crit Care Med. 2022;205(4):388-396.
UR  - https://doi.org/10.32322/jhsm.1507962
L1  - https://dergipark.org.tr/en/download/article-file/4034615
ER  -