TY - JOUR T1 - MEASLES-MUMPS-RUBELLA VACCINATION IN A PAEDIATRIC TRANSPLANT PATIENT USING EVEROLIMUS TT - EVEROLIMUS KULLANAN BİR PEDİATRİK TRANSPLANT OLGUSUNDA KIZAMIK-KABAKULAK-KIZAMIKÇIK AŞISI UYGULAMASI AU - Büke, Övgü AU - Kaçır, Aybüke AU - Karabayır, Nalan AU - Başıbüyük, Mine AU - Bilgin, Demet Deniz AU - Öcal, Özlem PY - 2025 DA - January Y2 - 2024 DO - 10.26650/IUITFD.1509646 JF - Journal of Istanbul Faculty of Medicine JO - İst Tıp Fak Derg PB - Istanbul University WT - DergiPark SN - 1305-6441 SP - 80 EP - 82 VL - 88 IS - 1 LA - en AB - There is limited information regarding the administration of live vaccines to paediatric transplant patients who are at increased risk of infection. A 7-year-old liver transplant patient who had everolimus therapy was evaluated for Measles-Mumps-Rubella (MMR) vaccination. After checking the lymphocyte count, immunoglobulin G, and serum everolimus levels, the MMR vaccine was administered. No side effects were observed during follow-up, and the antibody levels were found to be positive after two months. This article presents a case of paediatric solid organ transplantation patient who received a measles-mumps-rubella vaccination while receiving immunosuppressive everolimus therapy. KW - Child KW - vaccination KW - everolimus KW - solid organ transplantation N2 - İnfeksiyon riskinin artmış olduğu pediatrik transplantasyon hastalarında canlı aşıların uygulanması ile ilgili bilgiler sınırlı dır. Yedi yaşında, halen evorolimus kullanmakta olan karaciğer nakli hastası Kızamık-Kabakulak-Kızamıkçık (KKK) aşısı yapılmak amacıyla değerlendirildi. Lenfosit sayısı, immünoglobulin G ve serum everolimus düzeyleri kontrol edildikten sonra KKK aşısı uygulandı. İzlemde yan etki saptanmayan olguda, iki ay sonra bakılan antikor düzeyleri pozitif bulundu. Bu yazıda immüno supresif everolimus tedavisi alırken Kızamık-Kabakulak-Kıza mıkçık aşısı uygulanan bir pediatrik solid organ nakli olgusu sunulmaktadır. CR - Kamei K. Live attenuated vaccines in patients receiving immunosuppressive agents. Pediatr Nephrol 2023;38(12):3889-900. [CrossRef] google scholar CR - Coppeta L, Ferrari C, Somma G, Giovinazzo V, Buonomo E, Trabucco Aurilio M, et al. Serological Evaluation for Measles among Italian and Foreign Medical Students in a University Hospital in Rome. Vaccines 2023;11(7):1256. [CrossRef] google scholar CR - Feldman AG, Beaty BL, Curtis D, Juarez-Colunga E, Kempe A. Incidence of Hospitalization for Vaccine-Preventable Infections in Children Following Solid Organ Transplant and Associated Morbidity, Mortality, and Costs. JAMA Pediatr 2019;173(3):260-8. [CrossRef] google scholar CR - Liu Y, Sun LY, Zhu ZJ, Lin W, Qu W, Zeng ZG. Measles Virus Infection in Pediatric Liver Transplantation Recipients. Transplant Proc 2015;47(9):2715-8. [CrossRef] google scholar CR - Suresh S, Upton J, Green M, Pham-Huy A, Posfay-Barbe KM, Michaels MG, et al. Live vaccines after pediatric solid organ transplant: Proceedings of a consensus meeting, 2018. Pediatr Transplant 2019;23(7):e13571. [CrossRef] google scholar CR - Manzia TM, Antonelli B, Carraro A, Conte G, Guglielmo N, Lauterio A, et al. Immunosuppression in adult liver transplant recipients: a 2024 update from the Italian Liver Transplant Working Group. Hepatol Int 2024;18(5):1416-30 [CrossRef] google scholar CR - Shipkova M, Hesselink DA, Holt DW, Billaud EM, van Gelder T, Kunicki PK, et al. Therapeutic Drug Monitoring of Everolimus: A Consensus Report. Therapeutic Drug Monitoring 2016;38(2):143. [CrossRef] google scholar CR - Witzke O, Sommerer C, Arns W. Everolimus immunosuppression in kidney transplantation: What is the optimal strategy? Transplant Rev (Orlando) 2016;30(1):3-12. [CrossRef] google scholar CR - Keskindemirci G, Önal Z, Özbörü Aşkan Ö, Yücel E, Varol S, Hançerli Törün S, et al. Attenuated live vaccine in children with solid organ transplantation on everolimus therapy: Report of two cases. Pediatr Transplant 2023;27(2):e14426. [CrossRef] google scholar CR - Shinjoh M, Hoshino K, Takahashi T, Nakayama T. Updated data on effective and safe immunizations with live-attenuated vaccines for children after living donor liver transplantation. Vaccine 2015;33(5):701-7. [CrossRef] google scholar CR - Kawano Y, Suzuki M, Kawada J ichi, Kimura H, Kamei H, Ohnishi Y, et al. Effectiveness and safety of immunization with live-attenuated and inactivated vaccines for pediatric liver transplantation recipients. Vaccine 2015;33(12):1440-5. [CrossRef] google scholar CR - Hartley C, Thomas T, Smith SK, Karnsakul W. Live-Attenuated Vaccines in Pediatric Solid Organ Transplant. Vaccines 2024;12(4):376. [CrossRef] google scholar UR - https://doi.org/10.26650/IUITFD.1509646 L1 - https://dergipark.org.tr/en/download/article-file/4041652 ER -