@article{article_1511457, title={Periocular sebaceous carcinoma with intracranial extension: A case report}, journal={Deneysel ve Klinik Tıp Dergisi}, volume={42}, pages={343–345}, year={2025}, author={Cenberlitas, Elif Ezgi and Akbulut, Bilal Bahadır and Bölük, Mustafa Serdar and Yurtseven, Taşkın and Biçeroğlu, Hüseyin}, keywords={sebaceous gland neoplasm, intracranial neoplasms, craniotomy, case report}, abstract={Sebaceous carcinoma, typically originating from the meibomian glands of the eyelids, is a rare malignant tumor with a propensity for diffuse, invasive growth. Intracranial extension of this carcinoma is exceptionally rare, with only a few cases reported. A 63-year-old male was referred to our tertiary hospital with swelling and pain in his right eye. The examination findings for the right eye revealed proptosis, chemosis, corneal opacity obstructing the visual axis, a membrane across the pupil, a shallow anterior chamber, and poor fundus visualization. On radiological imaging, a malignant mass with extension to the cavernous sinus and the temporal lobe was detected. The patient underwent surgery using supraorbital craniotomy, and the pathology came out to be sebaceous carcinoma. A partial excision was carried out with the preservation of the anatomical structures. There were no postoperative complications. The patient received adjuvant radiotherapy and is recurrence-free in a 3-year follow-up. However, a secondary meningioma associated with prior radiotherapy was identified on follow-up imaging. Unfortunately, the patient experienced notable right hemifacial muscle atrophy and severe fibrosis, causing eyelid adhesion following radiotherapy. We contend that an operative intervention prioritizing functional conservation, in conjunction with adjunct radiotherapy, would be deemed appropriate. Close follow-up and individualized treatment planning are essential for ensuring the best outcomes in this patient population.}, number={3}, publisher={Ondokuz Mayıs University}