TY - JOUR T1 - Kardiyovasküler Hastalıklarda Koenzim Q10 Takviyesi: Moleküler Mekanizmalar ve Klinik Bulgular TT - Coenzyme Q10 Supplementation in Cardiovascular Diseases: Molecular Mechanisms and Clinical Evidence AU - Saruhan, Merve PY - 2025 DA - August Y2 - 2024 JF - Genel Sağlık Bilimleri Dergisi JO - JGEHES PB - Necmettin Erbakan University WT - DergiPark SN - 2687-5403 SP - 423 EP - 443 VL - 7 IS - 2 LA - tr AB - Koenzim Q10 (CoQ10),tüm hücre zarlarında doğal olarak bulunan, tüm dokularda endojen olarak sentezlenebilen, vitamin benzeri lipofilik redoks-aktif bir moleküldür. Başlıca görevi mitokondriyal elektron taşıma sisteminde yer alarak enerji üretimini sağlamaktır. Vücutta birçok biyokimyasal fonksiyonları bulunan bu molekülün en iyi bilinen diğer fonksiyonu reaktif oksijen türlerinden kaynaklanan oksidatif hasardan koruyucu güçlü antioksidan özelliğidir. Kalp kasları gibi yüksek enerjiye ihtiyaç duyan dokularda bol miktarda bulunmakta olup, kalp sağlığının korunması için kritik bir bileşen olarak kabul edilmektedir. Bilimsel çalışmalar, CoQ10 takviyesinin patogenezlerinde mitokondriyal disfonksiyon ve oksidatif stresin önemli rol oynadığı kalp yetmezliği, koroner arter hastalığı, hipertansiyon, miyokard enfarktüsü, dislipidemi gibi kardiyovasküler hastalıkların yönetiminde olumlu etkiler gösterebileceğini ortaya koymaktadır. Genel olarak güvenli bir besin desteği olarak belirtilen ve piyasada en yaygın kullanılan besin takviyeleri arasında yer alan CoQ10, kardiyovasküler fonksiyonların desteklenmesi ve ilgili semptomların hafifletilebilmesi için potansiyel bir nütrasötik olarak değerlendirilmektedir. KW - Besin Destekleri KW - Enerji Metabolizması KW - Kardiyovasküler Sistem KW - Koenzim Q10 KW - Oksidatif Stres. N2 - Coenzyme Q10 (CoQ10) is a vitamin-like, lipophilic, redox-active molecule found naturally in all cell membranes, and it can be synthesized endogenously in all tissues. Its primary function is to support energy production by participating in the mitochondrial electron transport chain. Another well-known function of this molecule, which has many biochemical roles in the body, is its potent antioxidant properties, which protect against oxidative damage caused by reactive oxygen species. CoQ10 is abundant in tissues that require high energy, such as the heart muscle, and is considered a crucial component for maintaining heart health. Scientific studies suggest that CoQ10 supplementation may have beneficial effects in managing cardiovascular diseases, such as heart failure, coronary artery disease, hypertension, myocardial infarction, and dyslipidemia, where mitochondrial dysfunction and oxidative stress play a significant role in their pathogenesis. 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