@article{article_1514488, title={COMPARISON OF ULTRASOUND-GUIDED TRUCUT NEEDLE BIOPSY AND LAPAROSCOPY IN THE DIAGNOSIS OF HIGH-GRADE SEROUS OVARIAN CANCER}, journal={Kocatepe Tıp Dergisi}, volume={26}, pages={5–9}, year={2025}, DOI={10.18229/kocatepetip.1514488}, author={Özdemir, Cem Yağmur and Arıöz, Dağhan Arda and Çiçekli, Nayif and Ahat, Betül and Çoşkun, Hüseyin and Demir, Hacer and Öner, Öznur and Arıöz, Dağıstan Tolga}, keywords={High- Grade Ovarian Carcinoma, Laparoscopy, Survival, Tru-cut Biopsy.}, abstract={OBJECTIVE: We aimed to compare tru-cut biopsy with laparoscopy
in the diagnosis of high-grade serous ovarian cancer
(HGSC) in our clinic.
MATERIAL AND METHODS: Our retrospective study included
patients who underwent surgery for HGSC between January
2013 and December 2023. Patients with pathologically confirmed
(FIGO 2018) stage III or IV HGSC underwent neoadjuvant
chemotherapy (NACT) and interval debulking surgery (IDS)
were performed. Exclusion criteria were patients with stage
I and II ovarian cancer and who did not receive NACT. Additionally,
patients with non-high-grade serous ovarian cancer or
non-gynecological conditions were excluded. As a result, 60
patients were included in the study. Participants were categorized
into two groups, namely, Group 1 (Patients diagnosed with
HGSC by tru-cut biopsy before NACT) and Group 2 (Patients diagnosed
with HGSC by diagnostic laparoscopy before NACT).
Time-to-event analyses were conducted using the Kaplan- Meier
method and log-rank test. Statistical significance was defined
when p < 0.05.
RESULTS: Out of the 60 patients, 32 patients were diagnosed
by tru-cut biopsy and 28 patients with laparoscopy. The overall
survival (OS) of Group 1 was 53.1%, and for Group 2, it was
71.4% (p = 0.371). The progression-free survival (PFS) rate was
56.3 for Group 1 and 64.3% for Group 2 (p = 0.464). No significant
difference was detected in terms of recurrence, OS and
PFS. We found a significant difference between Group 1 and
Group 2 only in terms of hospitalization time (p < 0.001).
CONCLUSIONS: HGSC is a histopathological subgroup of ovarian
cancer that is difficult to diagnose and manage. While primary
debulking surgery remains in the background, the importance
of tru-cut biopsy in terms of short hospital stay should
not be forgotten in the diagnostic evaluation of patients.}, number={1}, publisher={Afyonkarahisar Sağlık Bilimleri Üniversitesi}, organization={This research received no external funding.}