TY  - JOUR
T1  - Formulation and evaluation of orodispersible tablet of dolutegravir -methionine cocrystal
AU  - Bhattacharyya, Sayani
AU  - Tamang, Rejoys
AU  - Tamang, Ammon
PY  - 2025
DA  - March
Y2  - 2024
DO  - 10.55262/fabadeczacilik.1516443
JF  - Fabad Eczacılık Bilimler Dergisi
JO  - Fabad J Pharm Sci
PB  - FABAD Ankara Eczacılık Bilimleri Derneği
WT  - DergiPark
SN  - 1300-4182
SP  - 1
EP  - 14
VL  - 50
IS  - 1
LA  - en
AB  - Dolutegravir, a newly approved anti-HIV medication is insoluble in the normal gastric pH range and that results in slow onset of action. The research proposes cocrystallization process to increase the solubility of the drug and hence dissolution. The cocrystals of dolutegravir were formulated using methionine as coformers by solvent evaporation method. The cocrystals were evaluated for solubility, in vitro drug release, and solid-state characterization, study. The orodispersible tablets of dolutegravir cocrystal were successfully prepared by direct compression method. The solid-state characterization study showed the compatibility and amorphization of the drug in the cocrystal form. The cocrystal of drug: methionine (1:2) was found to enhance dissolution by 1.88 times compared to the pure drug. The orodispersible tablets disintegrated at 10.05 secs and 90% drug was released in 20 min. Hence, it can be concluded that the methionine-dolutegravir cocrystal can be a promising means to improve the solubility of the drug
KW  - Dolutegravir
KW  - CoCrystal
KW  - Solubility enhancement
KW  - orodispersible tablet
KW  - dissolution
CR  - Bhattacharyya, S., & Manjunath, A. (2023). Pharmaceutical
cocrystal-a deft technique for solubility
enhancement, Pharmaceutical Sciences
Asia, 50(4), 361-370. https://doi.org/:10.29090/
psa.2023.04.23.618.
UR  - https://doi.org/10.55262/fabadeczacilik.1516443
L1  - https://dergipark.org.tr/en/download/article-file/4071610
ER  -