@article{article_1531084, title={EXAMINING THE ROLE OF SUPAR AND HS-CRP LEVELS IN PREDICTING CORONARY ARTERY DISEASE SEVERITY IN ACUTE MYOCARDIAL INFARCTION: AN AGE-STRATIFIED ANALYSIS INCORPORATING SYNTAX SCORE}, journal={Meandros Medical And Dental Journal}, volume={25}, pages={365–378}, year={2024}, DOI={10.69601/meandrosmdj.1531084}, author={Ateş, Muhammet Salih and Tunçez, Abdullah and Yalcin, Muhammed Ulvi and Demir, Kenan and Aygül, Nazif and Altunkeser, Behlül Bülent and Tezcan, Hüseyin and Polat, Onur Can and Toprak, Aslıhan Merve and Ozturk, Bahadir}, keywords={suPAR, Hs-CRP, Young Myocardial Infarction, Elderly Myocardial Infarction}, abstract={ABSTRACT Objective: This study examines the association between traditional inflammatory biomarkers, suPAR levels in elderly and young myocardial infarction patients, and coronary artery disease severity. Materials and Methods: In this study, 332 participants, including 227 acute myocardial infarction (AMI) patients and 107 controls, underwent evaluation through Syntax Score analysis, suPAR, and hs-CRP level assessments. AMI patients were divided into young and elderly groups based on age. Syntax Score was utilized to ascertain the severity of coronary artery disease. Results: suPAR plasma concentrations were significantly higher in AMI patients compared to controls, with values of 2.76 (2.32-3.56) in the young MI group and 3.33 (2.43-4.41) in the elderly MI group, versus 2.33 (1.94-3.11) in the control group (p <0.001). Additionally, hs-CRP levels were notably elevated in the elderly MI groups (p <0.001). The ROC analysis identified threshold values for suPAR at 3.10 pg/mL and hs-CRP at 6.5 mg/dL to predict a Syntax Score of 23 or higher, with suPAR showing 74.7% sensitivity, 69.9% specificity, and an AUC of 0.811 (p <0.001). The sensitivity of Hs-CRP was 65.8%, the specificity was 60.2%, and the AUC was 0.700 (p <0.001). Conclusion: Our study reveals a pivotal relationship between inflammatory markers, particularly suPAR, and Syntax Score in MI patients, suggesting its potential in refining cardiovascular risk assessment and informing future diagnostic and therapeutic approaches for coronary artery disease management.}, number={4}, publisher={Aydin Adnan Menderes University}, organization={The study received funding support from the Selcuk University Scientific Research Projects Coordinatorship, under the project identifier 19102049.}