TY  - JOUR
T1  - Comparison of Static and Spect Images on Tc-99m-PYP Bone Scintigraphy in the Diagnosis of Cardiac Amyloidosis
AU  - Aydın Akpınar, Emine
AU  - Özcan, Pınar Pelin
AU  - Koç, Zehra Pınar
AU  - Gümüş, Adil
AU  - Yavan, Gökçe
PY  - 2025
DA  - January
Y2  - 2025
DO  - 10.71286/moi.1534280
JF  - Molecular Oncologic Imaging
PB  - Mersin University
WT  - DergiPark
SN  - 2791-965X
SP  - 39
EP  - 45
VL  - 4
IS  - 3
LA  - en
AB  - Amyloidosis is a systemic disease characterized by the extracellular accumulation of amyloid fibrils caused by misfolding of proteins. Cardiac amyloidosis has the worst prognosis of the type of organ involvements. The most common forms of cardiac amyloidosis are immunoglobulin light chain amyloidosis (AL) and transtretin (TTR) amyloidosis. The developing diagnostic methods give the clinician early diagnosis of cardiac amyloidosis. Scintigraphic imaging with Technetium (Tc-99m) labelled biphosponates may faciliate early detection of cardiac involvement and distinguish various forms of cardiac amyloidosis. Bone scintigraphy for evaluation of cardiac amyloidosis especially for ATTR type amyloidosis is one of the most sensitive imaging prosedures in recent years. In our study, we compared the 1st and 3rd hour planar and SPECT imaging to investigate the importance of the 3rd hour and the necessity of SPECT in cardiac amyloidosis (CA) imaging, which is one of the controversial topics from the Nuclear Medicine perspective.
KW  - cardiac amyloidosis
KW  - Tc-99m PYP
KW  - SPECT
KW  - Planar
KW  - Imaging
KW  - scintigraphy.
CR  - Martinez-Naharro, A., Treibel, T. A., Abdel-Gadir, A., Bulluck, H., Zumbo, G., Knight, D. S., Kotecha, T., Francis, R., Hutt, D. F., Rezk, T., Rosmini, S., Quarta, C. C., Whelan, C. J., Kellman, P., Gillmore, J. D., Moon, J. C., Hawkins, P. N., & Fontana, M. (2017). Magnetic Resonance in Transthyretin Cardiac Amyloidosis. Journal of the American College of Cardiology, 70(4), 466–477. https://doi.org/10.1016/j.jacc.2017.05.053
CR  - Brownrigg, J., Lorenzini, M., Lumley, M., & Elliott, P. (2019). Diagnostic performance of imaging investigations in detecting and differentiating cardiac amyloidosis: a systematic review and meta-analysis. ESC heart failure, 6(5), 1041–1051. https://doi.org/10.1002/ehf2.12511
CR  - Dorbala, S., Cuddy, S., & Falk, R. H. (2020). How to Image Cardiac Amyloidosis: A Practical Approach. JACC. Cardiovascular imaging, 13(6), 1368–1383. https://doi.org/10.1016/j.jcmg.2019.07.015
CR  - Parry, T. L., Melehani, J. H., Ranek, M. J., & Willis, M. S. (2015). Functional Amyloid Signaling via the Inflammasome, Necrosome, and Signalosome: New Therapeutic Targets in Heart Failure. Frontiers in cardiovascular medicine, 2, 25. https://doi.org/10.3389/fcvm.2015.00025
CR  - Çavuşoğlu, Y., Özpelit, E., Çelik, A., İkitimur, B., Kayıkçıoğlu, M., Tokgözoğlu, L., Tüfekçioğlu, O., & Yılmaz, M. B. (2019). Cardiac amyloidosis: Recent advances in the diagnosis and therapy. Kardiyak amiloidoz: Tanı ve tedavide yenilikler. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 47(Suppl 2), 1–34. https://doi.org/10.5543/tkda.2019.28035
CR  - Habib, G., Bucciarelli-Ducci, C., Caforio, A. L. P., Cardim, N., Charron, P., Cosyns, B., Dehaene, A., Derumeaux, G., Donal, E., Dweck, M. R., Edvardsen, T., Erba, P. A., Ernande, L., Gaemperli, O., Galderisi, M., Grapsa, J., Jacquier, A., Klingel, K., Lancellotti, P., Neglia, D., … Indian Academy of Echocardiography (2017). Multimodality Imaging in Restrictive Cardiomyopathies: An EACVI expert consensus document In collaboration with the "Working Group on myocardial and pericardial diseases" of the European Society of Cardiology Endorsed by The Indian Academy of Echocardiography. European heart journal. Cardiovascular Imaging, 18(10), 1090–1121. https://doi.org/10.1093/ehjci/jex034
CR  - Chen, W., Ton, V. K., & Dilsizian, V. (2018). Clinical Phenotyping of Transthyretin Cardiac Amyloidosis with Bone-Seeking Radiotracers in Heart Failure with Preserved Ejection Fraction. Current cardiology reports, 20(4), 23. https://doi.org/10.1007/s11886-018-0970-2
CR  - Treglia, G., Glaudemans, A. W. J. M., Bertagna, F., Hazenberg, B. P. C., Erba, P. A., Giubbini, R., Ceriani, L., Prior, J. O., Giovanella, L., & Slart, R. H. J. A. (2018). Diagnostic accuracy of bone scintigraphy in the assessment of cardiac transthyretin-related amyloidosis: a bivariate meta-analysis. European journal of nuclear medicine and molecular imaging, 45(11), 1945–1955. https://doi.org/10.1007/s00259-018-4013-4
CR  - Gillmore, J. D., Maurer, M. S., Falk, R. H., Merlini, G., Damy, T., Dispenzieri, A., Wechalekar, A. D., Berk, J. L., Quarta, C. C., Grogan, M., Lachmann, H. J., Bokhari, S., Castano, A., Dorbala, S., Johnson, G. B., Glaudemans, A. W., Rezk, T., Fontana, M., Palladini, G., Milani, P., … Hawkins, P. N. (2016). Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis. Circulation, 133(24), 2404–2412. https://doi.org/10.1161/CIRCULATIONAHA.116.021612.
CR  - Dorbala S, Bokhari S, Miller E, et. al. ASNC Practise Points, 99mTechnetium-Pyrophospahate Imaging for Transthyretin Cardiac Amyloidosis.
CR  - Bokhari, S., Castaño, A., Pozniakoff, T., Deslisle, S., Latif, F., & Maurer, M. S. (2013). (99m)Tc-pyrophosphate scintigraphy for differentiating light-chain cardiac amyloidosis from the transthyretin-related familial and senile cardiac amyloidoses. Circulation. Cardiovascular imaging, 6(2), 195–201. https://doi.org/10.1161/CIRCIMAGING.112.000132
UR  - https://doi.org/10.71286/moi.1534280
L1  - https://dergipark.org.tr/en/download/article-file/4149801
ER  -