TY  - JOUR
T1  - ANALYSIS OF NEW POTENTIAL HEMOGRAM BIOMARKERS IN PATIENTS PRESENTING TO THE EMERGENCY DEPARTMENT WITH EPILEPTIC SEIZURES Acil Servise Epileptik Nöbet ile Başvuran Hastalarda Yeni Potansiyel Hemogram Biyobelirteçlerinin Analizi
AU  - Çaltekin, İbrahim
AU  - Aygün, Ali
AU  - Tomakin, Mesut
AU  - Yazıcı, Ramiz
AU  - Albayrak, Güneş Seda
PY  - 2024
DA  - September
Y2  - 2024
DO  - 10.16919/bozoktip.1489352
JF  - Bozok Tıp Dergisi
PB  - Yozgat Bozok University
WT  - DergiPark
SN  - 2146-4006
SP  - 144
EP  - 151
VL  - 14
IS  - 3
LA  - tr
AB  - ABSTRACTObjective: We aimed to analyze the diagnostic value of new potential hemogram biomarkers in patientspresenting to the emergency department with epileptic seizures.Material and Methods: Patients presenting with epileptic seizures to a tertiary hospital's emergency departmentbetween January 1, 2023, and January 1, 2024, were retrospectively reviewed. The patients werecategorized into Group A (seizure patients) and Group B (healthy volunteers). Hemogram and biochemistrydata from routine blood tests were examined. To predict seizure status, ROC analysis was performed toevaluate NLR, PLR and PNR. The area under the curve and cutoff values were calculated for each marker.Results: Our study examined two groups: seizure patients and the control group. The mean age of the seizuregroup was 50.31±1.83 years, and the mean age of the control group was 49.58±1.96 years (p>0.05). Inthe seizure group (n=116), 55.8% were male and 44.2% were female, whereas in the control group (n=104),57.8% were male and 42.2% were female (p>0.05). WBC, neutrophil count, NLR, and PLR values were significantlyhigher in seizure patients compared to the control group (p<0.001, p<0.001, p<0.001, and p=0.035,respectively). PNR and lymphocyte values were significantly lower in seizure patients compared to the controlgroup (p<0.001 and p=0.01, respectively).Conclusion: We found significant changes in NLR, PLR, and PNR values in patients with epileptic seizures.We believe that these biomarkers can assist clinicians in diagnosing seizures and distinguishing betweenseizures and pseudoseizures, especially in emergency departments.
KW  - ANALYSIS OF NEW POTENTIAL HEMOGRAM
BIOMARKERS IN PATIENTS PRESENTING TO THE
KW  - EMERGENCY DEPARTMENT WITH EPILEPTIC SEIZURES
KW  - Acil Servise Epileptik Nöbet ile Başvuran Hastalarda Yeni
Potansiyel Hemogram Biyobelirteçlerinin Analizi
CR  - 1. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Vd. ILAE Official Report: A Practical Clinical Definition of Epilepsy. Epilepsia. 2014;55(4):475-82.
CR  - 2. Calisir N, Bora I, Irgil E, Boz M. Prevalence of Epilepsy in Bursa City Center, an Urban Area of Turkey. Epilepsia. 2006;47(10):1691-9.
CR  - 3. Icagasıoglu Df. Etiology and Risk Factors of Epilepsy. Basic Pediatr Neurology Diagnosis and Treatment. 2022;2091-98.
CR  - 4. Manford M. Recent Advances in Epilepsy. J Neurol. 2017;264(8):1811-24.
CR  - 5. Akdag G, Algın D, Erdinç O. Epılepsy. Osmangazi Journal of Medicine 2016;38(1).
CR  - 6. Banote RK, Akel S, Zelano J. Blood Biomarkers in Epilepsy. Acta Neurol Scand. 2022;146(4):362-8.
CR  - 7. Sabers A, Kjær TW. Epilepsi. Ugeskr Læg Online. 2014;176(26):1232-5.
CR  - 8. Hampel KG, Garces-Sanchez M, Gomez-Ibanez A, Palanca-Camara M, Villanueva V. Diagnostic Challenges in Epilepsy. Rev Neurol. 2019;68(6):255-63.
CR  - 9. Cakıl D, Inanir S, Baykan H, Aygun H, Kozan R. Psychogenic Non-Epileptic Seizures in the Differential Diagnosis of Epilepsy. Goztepe Journal of Medicine. 2013;28(1):41-7.
CR  - 10. Huang Y, Ying Z, Quan W, Xiang W, Xie D, Weng Y, et al. The Clinical Significance of Neutrophil-To-Lymphocyte Ratio and Monocyte-To-Lymphocyte Ratio in Guillain-Barré Syndrome. Int J Neurosci. 2018;128(8):729-35.
UR  - https://doi.org/10.16919/bozoktip.1489352
L1  - https://dergipark.org.tr/en/download/article-file/4215032
ER  -