TY  - JOUR
T1  - Effects of vascularization when different alloplastic implant materials are used in adjacently with acellular dermal matrix
AU  - Karagül, Meryem İlkay
AU  - Fariz, Sevin
AU  - Yılmaz, Şakir Necat
AU  - Demiray Asoğlu, Zehra
AU  - Türkegün Şengül, Merve
PY  - 2025
DA  - April
Y2  - 2025
DO  - 10.17944/interdiscip.1552447
JF  - Interdisciplinary Medical Journal
JO  - Interdiscip Med J
PB  - Hatay Mustafa Kemal University
WT  - DergiPark
SN  - 2980-1915
SP  - 25
EP  - 32
VL  - 16
IS  - 54
LA  - en
AB  - Objective: Autologous tissue transplantation is the best way to repair tissue defects. Autologous graft materials can cause in the formation of scars and, in some cases, a reduction in the functionality of the donor site. This study aimed to ascertain how often revascularization in the acellular dermal matrix (ADM) is formed when different types of alloplastic implant materials are used in reconstructions.Method: The Wistar albino rats were assigned to three groups (n=7): various alloplastic materials (porous polyethylene, titanium, tricalcium phosphate, silicone), coated with ADM, were placed in distinct subcutaneous pockets on the thoracodorsal region of the rats, at 7, 14, and 21 days post-procedure, the rats were sacrificed for sampling. Sections were stained with hematoxylin-eosin. The degree of revascularization was assessed through the use of immunohistochemical labelling (anti-CD105 antibody).Results: The results indicated that minimal revascularization was observed on day 7, while significantly increased revascularization was evident on days 14 and 21. The use of alloplastic materials showed a significant increase in the number of CD105-positive vessels on days 7, 14 and 21. There was an increase in the number of CD105-positive vessels on day 21 compared to day 7. There was no significant difference in the number of CD105-positive vessels between days 7 and 14 in the tricalcium phosphate and silicone groups.Conclusion: The study concluded that distinct alloplastic implants used adjacent to ADM have no negative impact on revascularization rates. This is the most sought-after objective in the field of soft tissue reconstruction.
KW  - Acellular dermal matrix
KW  - Alloplastic material
KW  - Vascularization
KW  - Immunohistochemistry
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UR  - https://doi.org/10.17944/interdiscip.1552447
L1  - https://dergipark.org.tr/en/download/article-file/4224869
ER  -