TY  - JOUR
T1  - Encapsulation of Some Flavonoid Mixtures Using Electrospinning Technique for Enhanced Bioactivity and Controlled Release Studies
TT  - Artırılmış Biyoaktivite için Bazı Flavonoid Karışımlarının Elektroeğirme Tekniği Kullanılarak Enkapsülasyonu ve Kontrollü Salım Çalışmaları
AU  - Algan, Deniz Tuğçe
AU  - Kocabaş, Erdal
PY  - 2025
DA  - April
Y2  - 2024
JF  - Necmettin Erbakan Üniversitesi Fen ve Mühendislik Bilimleri Dergisi
JO  - NEU Fen Muh Bil Der
PB  - Necmettin Erbakan University
WT  - DergiPark
SN  - 2667-7989
SP  - 141
EP  - 152
VL  - 7
IS  - 1
LA  - en
AB  - Polymer-based electrospun fibers were prepared using bioactive compounds derived from citrus fruits such as rutin hydrate, naringin and hesperidin. These flavonoids have various biological activities such as antioxidant, anti-inflammatory and anticancer. By increasing the bioavailability of flavonoids through the electrospinning technique, it is aimed to develop potential applications in different areas such as drug delivery systems, food packaging and cosmetic products. The distribution and release behaviors of flavonoids in the fiber matrix were determined by morphological and chemical characterization of the obtained fibers. At the same time, the antibacterial activity of nanofibers against Staphylococcus aureus (S. aureus) bacteria was evaluated. As a result of the study, in the dissolution analysis performed at intestinal pH (pH 7.4), the active ingredients of PLA-MIX fiber were released at a rate of 20-25% and PCL-MIX fiber at a rate of 21-28%. Antibacterial results showed that nanofibers caused more bacterial inhibition in a 45% PLA mixture. This study provides an important contribution to the evaluation of citrus wastes and the development of new-generation biomaterials.
KW  - Antibacterial effect
KW  - Electrospinning
KW  - Flavonoid
KW  - Hesperidin
KW  - in vitro drug release
KW  - Naringin
KW  - Rutin hydrate
N2  - Narenciye meyvelerinden elde edilen biyoaktif bileşikler olan rutin hidrat, naringin ve hesperidin kullanılarak polimer bazlı elektroeğirme fiberleri hazırlanmıştır. Bu flavonoidlerin antioksidan, anti-inflamatuar ve anti-kanser gibi çeşitli biyolojik aktiviteleri bulunmaktadır. Elektroeğirme tekniği sayesinde, flavonoidlerin biyolojik kullanılabilirliği artırılarak, ilaç taşıma sistemleri, gıda ambalajları ve kozmetik ürünler gibi farklı alanlarda potansiyel uygulamalar geliştirilmesi amaçlanmıştır. Elde edilen fiberlerin morfolojik ve kimyasal ve karakterizasyonları ile flavonoidlerin fiber matris içerisindeki dağılımı ve salım davranışları belirlenmiştir. Aynı zamanda, nanofiberlerin Staphylococcus aureus (S. aureus) bakterisine karşı antibakteriyel aktivitesi değerlendirildi. Yapılan çalışmanın sonucunda bağırsak pH’ında (pH 7,4) yapılan dissolüsyon analizinde PLA-MIX fiberi etken maddeleri %20-25 oranında, PCL- MIX fiberi etken maddeleri %21-28 oranında salındı. Antibakteriyel sonuçlar nanofiberlerin %45 oranında PLA karışımında daha fazla bakteriyel inhibisyona neden olduğunu gösterdi. Bu çalışma, narenciye atıklarının değerlendirilmesi ve yeni nesil biyomalzemelerin geliştirilmesi açısından önemli bir katkı sağlamaktadır.
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UR  - https://dergipark.org.tr/en/pub/neufmbd/issue//1555804
L1  - https://dergipark.org.tr/en/download/article-file/4239716
ER  -