TY - JOUR T1 - Erişkin Still Hastalığında İnterlökin-1 İnhibitörü Tedavisinin Etkinlik ve Yan Etkilerinin Değerlendirilmesi TT - Evaluation of the Efficacy and Side Effects of Interleukin-1 Inhibitor Therapy in Adult Still's Disease AU - Ocak, Tuğba AU - Yağız, Burcu AU - Coskun, Belkis Nihan AU - Pehlivan, Yavuz AU - Dalkılıç, Hüseyin Ediz PY - 2025 DA - January Y2 - 2024 DO - 10.32708/uutfd.1559614 JF - Journal of Uludağ University Medical Faculty JO - Uludağ Tıp Derg PB - Bursa Uludağ University WT - DergiPark SN - 1300-414X SP - 391 EP - 396 VL - 50 IS - 3 LA - tr AB - Erişkin Still hastalığı (ESH) multigenik otoinflamatuar bir hastalıktır. İnterlökin (IL)-1 inhibitörleri tedaviye dirençli ESH’de kullanılabilir. Çalışmamızda ESH’de IL-1 inhibitörlerinin etkinlik ve yan etkileri ile ilgili gerçek yaşam deneyimimizi sunmayı amaçladık. Hastanemiz romatoloji kliniğinde Ocak 2016-Mart 2024 tarihleri arasında ESH tanısı ile takip edilen 24 hastanın dosyası retrospektif olarak incelendi. Anakinra alan 22 hasta ve kanakinumab alan 5 hasta mevcuttu. Kanakinumab alan hastalardan 3 tanesi daha önce anakinra tedavisi almıştı. Çalışmaya dahil edilen hastaların ortalama tanı yaşı 29,7 (16,5-75,3) yıldı. Hastaların 16’sı kadındı. Anakinra alan hastaların ortanca takip süresi 13,5 (0,8-92,5) ay saptandı. Hastaların anakinra başlangıç, 3. ay ve son vizitleri arasında ateş, boğaz ağrısı, döküntü, artrit, artralji, modifiye Pouchot skoru, ferritin, sedimentasyon ve C-reaktif protein parametrelerinde istatistiksel açıdan anlamlı fark mevcuttu (p KW - Anakinra KW - Erişkin Still Hastalığı KW - Kanakinumab. N2 - Adult Still's disease (ASD) is a multigenic autoinflammatory disease. Interleukin (IL)-1 inhibitors can be used in treatment-resistant ASD. We aimed to present our experience with the efficacy and side effects of IL-1 inhibitors in ASD. The records of 24 patients who were treated in the rheumatology clinic of our hospital between January 2016 and March 2024 with a diagnosis of ASD were retrospectively analyzed. There were 22 patients who received anakinra and 5 patients who received kanakinumab. Three of the patients receiving kanakinumab had previously been treated with anakinra. The mean age at diagnosis was 29.7 (16.5-75.3) years. Sixteen of the patients were female. The median follow-up time of patients who received anakinra was 13.5 (0.8-92.5) months. There were statistically significant differences in fever, sore throat, rash, arthritis, arthralgia, modified Pouchot score, ferritin, erythrocyte sedimentation rate (ESR) and C-reactive protein between baseline anakinra, month 3 and the last visit (p CR - 1.Jamilloux Y, Gerfaud-Valentin M, Henry T, Sève P. Treatment of adult-onset Still's disease: a review. 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