TY - JOUR T1 - The Effects of Natural and Artifical Sweeteners on Glucose Intolerance, Liver Enzymes and Oxidative Stress in Rats with Type 2 Diabetes TT - Tip 2 Diyabetli Ratlarda Doğal ve Yapay Tatlandırıcıların Glukoz İntoleransı, Karaciğer Enzimleri ve Oksidatif Stres Üzerine Etkisi AU - Pehlivan, Merve AU - Köksal, Eda PY - 2024 DA - December Y2 - 2024 DO - 10.37989/gumussagbil.1560223 JF - Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi JO - Gümüşhane Sağlık Bilimleri Dergisi PB - Gumushane University WT - DergiPark SN - 2146-9954 SP - 1518 EP - 1526 VL - 13 IS - 4 LA - en AB - The impacts of artificial and sweeteners on liver enzymes, glucose intolerance, and oxidative stress were investigated in the present research.Sixty adult male Wistar rats were indiscriminately distributed to two groups, involving 30 in each. The first group was made diabetic with streptozocin, and the second group was called the healthy control group. Then, these groups were divided into 3 different groups again and these groups were given 250 mg/kg daily of Aspartame and Stevia and followed for 5 weeks to compare their effects.A comparison between the groups indicated that the diabetic stevia group had lower levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood glucose, and HbA1c values than the diabetic aspartame group (p KW - Sweeteners KW - Glucose Intolerance KW - Liver Enzymes KW - Oxidative Stress N2 - Bu çalışmanın amacı, doğal ve yapay tatlandırıcıların glukoz intoleransı, karaciğer enzimleri ve oksidatif stres üzerine etkisini araştırmaktır. Altmış adet erişkin erkek Wistar rat, rastgele her grupta 30 adet olacak şekilde 2 gruba ayrılmştır. İlk grup streptozosin ile diyabetik yapılmış, ikinci grup ise sağlıklı kontrol grubu olarak adlandırılmıştır. Daha sonrasında bu gruplar kendi aralarında tekrar 3 farklı gruba ayrılmış ve bu gruplaraAspartam ve Stevia günlük 250 mg/kg şeklinde verilmiş ve etkilerini karşılaştırmak için 5 hafta boyunca takip edilmiştirDiyabetik aspartam grubu ile karşılaştırıldığında diyabetik stevia grubunun alanin aminotransferaz (ALT), aspartat aminotransferaz (AST), kan glukoz seviyeleri ve HbA1c değerleri diyabetik aspartam grubuna göre düşük bulunmuştur (p CR - 1. Kim, E, Shin, J. H, Seok, P.R, Kim, M.S, Yoo, S. H. and Kim, Y. (2018). “Phyllodulcin, a natural functional sweetener, improves diabetic metabolic changes by regulating hepatic lipogenesis, inflammation, oxidative stress, fibrosis, and gluconeogenesis in db/db mice”. Journal of Functional Foods, 42, 1-11. https://doi.org/10.1016/j.jff.2017.12.038 CR - 2. Khan, T. A, Ayoub-Charette, S, Sievenpiper, J. L. and Comelli, E. M. 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