TY  - JOUR
T1  - Pathomorphological approach on canine sebaceous tumors
AU  - Yücel Tenekeci, Gözde
AU  - Tunç, Arda Selin
AU  - Demirtaş, Oya Burçin
PY  - 2024
DA  - December
Y2  - 2024
DO  - 10.24880/meditvetj.1561120
JF  - Mediterranean Veterinary Journal
JO  - MeditVetJ
PB  - Burdur Mehmet Akif Ersoy University
WT  - DergiPark
SN  - 3023-8447
SP  - 403
EP  - 409
VL  - 9
IS  - 3
LA  - en
AB  - Sebaceous neoplasms are among the most frequently observed skin tumors in dogs. The histological classification of sebaceous glands (including Meibomian glands) is made according to sebocyte and basaloid reserve cell components. In this study aiming to examine sebaceous tumors in detail, 28 biopsies diagnosed with sebaceous neoplasia, including Meibomian gland neoplasia, were examined and diagnosed as adenoma (n:9), epithelioma (n:12), and carcinoma (n:7). Histopathologically; cell ratios (sebaceous/basal), appearance (diffuse/multilobular), presence of ulcers, necrosis, inflammation, pleomorphism and mitosis were evaluated. Ki-67 biomarker was used immunohistochemically to demonstrate cell division. Based on histopathological and immunohistochemical examinations, it was determined that epitheliomas would rather be classified as low-grade malignancy due to the apparent mitotic activity and should be examined in more detail.
KW  - canine
KW  - epithelioma
KW  - Ki-67
KW  - malignancy
KW  - sebaceous tumors
CR  - Bertram, C. A., Donovan, T. A., & Bartel, A. (2024). Mitotic activity: A systematic literature review of the as-sessment methodology and prognostic value in canine tu-mors. Veterinary pathology, 27;61(5):752–764. https://doi. org/10.1177/03009858241239565
CR  - Costa, F. B., da Silva, K. V. G. C., da Silva Leite, J., Silva, F. B. F., dos Santos Batista, B. P., de Melo, J. F., & Ferreira, A. M. R. (2020). Histopathological study of canine sebaceous tumors and their association with PCNA expression by immunohis-tochemistry. Revista Brasileira de Ciência Veterinária, 27(3). https://doi.org/10.4322/rbcv.2020.027
CR  - De Las Mulas, J. M., Millan, Y., Ruiz-Villamor, E., Bautista, M. J., Rollon, E., & De Los Monteros, A. E. (1999). Apoptosis and mitosis in tumours of the skin and subcutaneous tissues of the dog. Research in veterinary science, 66(2), 139-146. https://doi.org/10.1053/rvsc.1998.0260
CR  - Gerdes, J., Schwab, U., Lemke, H., & Stein, H. (1983). Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. International journal of cancer, 31(1), 13-20. https://doi. org/10.1002/ijc.2910310104
CR  - Goldschmidt M.H., Goldschmidt K.H. (2017). Epithelial and Melanocytic Tumors of the Skin. In: D. J. Meuten (Ed.). Tumors in Domestic Animals (pp. 88-141). Iowa State Press. https://doi.org/10.1002/9781119181200.ch4
Hendrick, M.J. (2016). Mesenchymal tumors of the skin and soft tissues. Tumors in domestic animals (pp. 142-175). https://doi.org/10.1002/9781119181200.ch5
CR  - Keleş, Ö. F., Kuşçu, Y., Kayıkçı, C., & Çiçek, H. A. (2024). Sebaceous gland epithelioma with potential malignancy in a dog. Mediterranean Veterinary Journal, 9(2), 333-336. https://doi.org/10.24880/meditvetj.1541593
CR  - Kim, S., Chaudhary, P. K., Upadhayaya, S., Seo, K. W., & Kim, S. (2024). Histopathological and Immunohistochemical Characterization of Sebaceous Adenoma and Epithelioma in Dogs. Animals, 14(10), 1457. https://doi.org/10.3390/ani14101457
CR  - Li, L. T., Jiang, G., Chen, Q., & Zheng, J. N. (2015). Ki67 is a promising molecular target in the diagnosis of cancer. Molecular medicine reports, 11(3), 1566-1572. https://doi. org/10.3892/mmr.2014.2914
CR  - Proskuryakov, S. Y., & Gabai, V. L. (2010). Mechanisms of tumor cell necrosis. Current pharmaceutical design, 16(1), 56-68. https://doi.org/10.2174/138161210789941793
CR  - Scholzen, T., & Gerdes, J. (2000). The Ki‐67 protein: from the known and the unknown. Journal of cellular physiology, 182(3), 311-322. https://doi.org/10.1002/(SICI)1097-4652
CR  - Starborg, M., Gell, K., Brundell, E., & Höög, C. (1996). The murine Ki-67 cell proliferation antigen accumulates in the nu-cleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essen-tial for cell cycle progression. Journal of cell science, 109(1), 143-153. https://doi.org/10.1242/jcs.109.1.143
CR  - Sun, X., & Kaufman, P. D. (2018). Ki-67: more than a pro-liferation marker. Chromosoma, 127, 175-186. https://doi. org/10.1007/s00412-018-0659-8
CR  - Vail, D. M., & Withrow, S. J. (2007). Tumors of the skin and subcutaneous tissues. Withrow, SJ; Macewen, EG Small animal clinical oncology, 4, 375-401.
UR  - https://doi.org/10.24880/meditvetj.1561120
L1  - https://dergipark.org.tr/en/download/article-file/4262677
ER  -