@article{article_1563161, title={The Role of Stressful Life Events in Breast Cancer Etiology}, journal={Balıkesir Atatürk Şehir Hastanesi Tıp Dergisi}, volume={1}, pages={1–6}, year={2024}, author={İriağaç, Yakup and Çavdar, Eyyüp and Karaboyun, Kubilay and Avcı, Okan and Beyazyüz, Elmas and Şeber, Erdoğan Selçuk}, keywords={Breast cancer, Sarason, Stressful Life Events}, abstract={INTRODUCTION: This study aimed to investigate the relationship between stressful life events experienced in the last year and breast cancer. METHODS: Measurements were made with the Life Experiences Survey developed by Sarason. The sum of the scores perceived as negative was calculated separately as the negative life experiences score (NegLES), and the sum of the scores reported as positive was calculated separately as the positive life experiences score (PosLES). The sum of the two scores was evaluated as the total life experience score (TotLES). RESULTS: A total of 278 participants, 139 patients with breast cancer and 139 diagnosed with breast fibrocystic disease (control), were included in this study. The median age of all participants was 48 (range:21-75). The median age of the cancer group was 49 years (range: 26-75) and the median age of the control group was 48 years (range 21-71)(p=0.118). The mean of NegLES was -7.0±6.5 in cancer patients and 4.6±5.7 in control group and the mean TotLES was -5.9±6.6 in cancer patients and -3.5±6.3 in control group (for both, p=0.001). PosLES was similar for both groups (p=0.697). Compared to the control group, absolute low NegLES (OR: 0.938 95% CI 0.900-0.977, p=0.002) and absolute low TotLES (OR: 0.942 95% CI 0.906-0.979, p=0.002) were associated with decreased breast cancer. PosLES did not predict breast cancer (OR: 0.988 95% CI 0.891-1.095, p=0.813). DISCUSSION AND CONCLUSION: It was concluded that the negative life events experienced by women in the last year contributed to the risk of breast cancer.}, number={1}, publisher={Balıkesir Atatürk Şehir Hastanesi}