TY  - JOUR
T1  - EFFECTS OF PLATELET-RICH PLASMA AND OZONE THERAPY ON PAIN AND QUALITY OF LIFE IN KNEE OSTEOARTHRITIS: A RETROSPECTIVE TRIAL
TT  - DİZ OSTEOARTRİTİNDE TROMBOSİTTEN ZENGİN PLAZMA VE OZON TEDAVİSİNİN AĞRI VE YAŞAM KALİTESİ ÜZERİNE ETKİLERİ: RETROSPEKTİF ÇALIŞMA
AU  - Ayyıldız, Aylin
AU  - Çiftci İnceoğlu, Selda
AU  - Kuran, Banu
PY  - 2025
DA  - April
Y2  - 2024
DO  - 10.26650/IUITFD.1567904
JF  - Journal of Istanbul Faculty of Medicine
JO  - İst Tıp Fak Derg
PB  - Istanbul University
WT  - DergiPark
SN  - 1305-6441
SP  - 98
EP  - 101
VL  - 88
IS  - 2
LA  - en
AB  - Objective: There are many methods for treating knee osteoarthritis (KOA). However, especially among conservative treatments, intra articular injection methods have not been shown to be superior to each other. In our study, we compared the effects of ozone therapy and platelet-rich plasma on pain and functionality.Material and Methods: This retrospective clinical study included patients aged 30-70 years who received ozone and Platelet-Rich Plasma (PRP) for the treatment of knee osteoarthritis. Both groups received 3 sessions of ultrasound-guided intra-articular injection. The demographic characteristics of the patients, such as age and gender, were recorded. Pain was assessed with a numerical rating scale (NRS) before and 3 months after treatment, functionality with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and quality of life with the Short Form-12 (SF-12).Results: The mean age of the 54 patients included in the study was 58.53±8.25 years. No significant difference was found between the two groups in terms of age, gender, pre-treatment NRS, WOMAC, and SF-12 values. There were significant differences in the NRS, WOMAC, and SF-12 values in both ozone and PRP groups after treatment compared to before treatment. However, this difference was not found to be significant between the groups.Conclusion: Both PRP and ozone therapy are effective short term treatments for KOA. There is no evidence that one is more effective than the other.
KW  - Knee osteoarthritis
KW  - ozone
KW  - pain
KW  - platelet-rich plasma
KW  - quality of life
N2  - Amaç: Diz osteoartritinin (DOA) tedavisi için birçok yöntem vardır. Ancak özellikle konservatif tedaviler arasında eklem içi enjeksiyon yöntemlerinin birbirlerine üstünlüğü gösterilememiştir. Çalışma mızda, ozon tedavisi ve trombositten zengin plazmanın ağrı ve fonksiyonellik üzerindeki etkilerini karşılaştırmayı amaçladık.Gereç ve Yöntem: Bu retrospektif klinik çalışmaya diz osteoartriti tedavisi için ozon ve trombositten zengin plazma (PRP) alan 30-70 yaş arası hastalar dahil edildi. Her iki gruba da 3 seans ultrason eşliğinde eklem içi enjeksiyon uygulandı. Hastaların yaş ve cinsiyet gibi demografik özellikleri kaydedildi. Ağrı tedaviden önce ve 3 ay sonra sayısal derecelendirme ölçeği (NRS) ile, işlevsellik Western Ontario ve McMaster Üniversiteleri Osteoartrit İndeksi (WOMAC) ile ve yaşam kalitesi Kısa Form-12 (SF-12) ile değerlendirildi.Bulgular: Çalışmaya dahil edilen 54 hastanın yaş ortalaması 58,53±8,25 yıl idi. İki grup arasında yaş, cinsiyet, tedavi öncesi NRS, WOMAC ve SF-12 değerleri açısından anlamlı bir fark bulunmadı. Hem ozon hem de PRP gruplarında tedavi sonrası NRS, WOMAC ve SF-12 değerlerinde tedavi öncesine göre anlamlı farklılıklar var dı. Ancak bu fark gruplar arasında anlamlı bulunmamıştır.Sonuç: Hem PRP hem de ozon tedavisi DOA için etkili kısa süreli tedavilerdir. Birinin diğerinden daha etkili olduğuna dair bir kanıt saptanmamıştır.
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UR  - https://doi.org/10.26650/IUITFD.1567904
L1  - https://dergipark.org.tr/en/download/article-file/4290710
ER  -