@article{article_1572970, title={HOW TO MANAGE POST-OPERATIVE PAIN AFTER LAPAROSCOPIC CHOLESYSTECTOMY? COMPARISON OF THREE DISTINCT APPROACHES: A PROSPECTIVE RANDOMIZED CONTROLLED STUDY}, journal={Atlas Journal of Medicine}, volume={5}, pages={12–18}, year={2025}, DOI={10.54270/atljm.2025.77}, author={Şenol, Zafer and Ertürk, Tuna and Gülşen, Taygun and Yıldırak, Muhammed Kadir and Metin Yamaç, Dilek and Kızıltoprak, Nurhilal and Genç, Mahmut Salih and İşçeviren, Bora and Bölük, Sümeyra Emine and Karadağ, Merve and et al.}, keywords={Laparoscopic cholecystectomy, Transverse abdominis plane block, Port site local anesthetic injection, Gallbladder bed local anesthetic spraying, Pain management}, abstract={Aim: Laparoscopic Cholecystectomy (LC) is one of the most performed surgeries in daily general surgery practice and inadequate pain relief following surgery is associated with prolonged hospital stay. Transverse abdominis plane block (TAPB), port site local anesthetic injection (PSLAI) and gallbladder bed local anesthetic spraying (GBLAS) account for a part of numerous pain management strategies. In this study, we aimed to compare post-operative pain after laparoscopic cholecystectomy in transverse abdominis plane block (TAPB), port site local anesthetic injection (PSLAI) and gallbladder bed local anesthetic spraying (GBLAS) approaches. Materials and Methods: 99 patients were randomized into 3 groups. Patient-Controlled Analgesia (PCA) was utilized, and total analgesic demand and dosage were recorded along with Numerical Rating Scale (NRS) values at post-operative (p.o) 2, 6, 12 and 24 hours. Results: At p.o 24 hours, there was no statistically significant difference between groups in terms of PCA readings. However, NRS values were significantly higher in PSLAI group compared to TAPB and GBLAS groups. Conclusion: This study is unique as it compares the three methods in a single trial. While GBLAS gains slightly more attention as it is associated with a shorter procedure, all three methods are viable and might even be combined. We believe this study will pave way for future randomized controlled trials (RCT) in this regard.}, number={12}, publisher={Atlas University}