TY - JOUR T1 - Iatrogenic Esophageal Perforation in Extremely Preterm Infants: A Report of Three Cases TT - Iatrogenic Esophageal Perforation in Extremely Preterm Infants: A Report of Three Cases AU - Adak, Ayşe Melike AU - Durak, Fatma AU - Kara, Mehmet Baki AU - İsbir, Caner AU - Orman, Ayşen AU - Çelik, Yalçın PY - 2025 DA - July Y2 - 2024 DO - 10.26650/jchild.2025.1573234 JF - Çocuk Dergisi PB - Istanbul University WT - DergiPark SN - 1308-8491 SP - 55 EP - 59 VL - 25 IS - 1 LA - en AB - Iatrogenic esophageal perforation in neonates is a rare but serious complication that can occur during medical interventions. Early diagnosis and intervention are of vital importance. In recent years, surgical treatment has been replaced by conservative approaches. In this article, three cases of esophageal perforation that developed during the insertion of an orogastric (O/G) tube are presented. KW - Esophagus KW - neonate KW - perforation N2 - Iatrogenic esophageal perforation in neonates is a rare but serious complication that can occur during medical interventions. Early diagnosis and intervention are of vital importance. In recent years, surgical treatment has been replaced by conservative approaches. In this article, three cases of esophageal perforation that developed during the insertion of an orogastric (O/G) tube are presented. CR - Rentea RM, St. Peter SD. Neonatal and pediatric esophageal perforation. Semin Pediatr Surg. 2017;26(2):87-94. doi:10.1053/j.sempedsurg.2017.02.005 google scholar CR - Dökümcü ÜZ, Özcan, Özofagus perforasyonu-mediastinit. Çocuklarda Cerrahi Göğüs Hastalıkları. 2020;1:209-214 google scholar CR - Brinster CJ, Singhal S, Lee L, Marshall MB, Kaiser LR, Kucharczuk JC. Evolving options in the management of esophageal perforation. Annals of Thoracic Surgery. 2004;77(4):1475-1483. doi:10.1016/j.athoracsur.2003.08.037 google scholar CR - Onwuka EA, Saadai P, Boomer LA, Nwomeh BC. Nonoperative management of esophageal perforations in the newborn. Journal of Surgical Research. 2016;205(1):102-107. doi:10.1016/j.jss.2016.06.027 google scholar CR - Hesketh AJ, Behr CA, Soffer SZ, Hong AR, Glick RD. Neonatal esophageal perforation: Nonoperative management. Journal of Surgical Research. 2015;198(1):1-6. doi:10.1016/j.jss.2015.05.018 google scholar CR - Yong SB, Ma JS, Chen FS, Chung MY, Yang KD. Nasogastric Tube Placement and Esophageal Perforation in Extremely Low Birth Weight Infants. Pediatr Neonatol. 2016;57(5):427-430. doi:10.1016/j.pedneo.2013.10.011 google scholar CR - Mileder LP, Müller M, Reiterer F et al. Esophageal Perforation with Unilateral Fluidothorax Caused by Nasogastric Tube. Case Rep Pediatr. 2016;2016:1-2. doi:10.1155/2016/4103734 google scholar CR - Sepesi B, Raymond DP, Peters JH. Esophageal perforation: Surgical, endoscopic and medical management strategies. Curr Opin Gastroenterol. 2010;26(4):379-383. doi:10.1097/MOG.0b013e32833ae2d7 google scholar CR - Sorensen E, Yu C, Chuang SL, et al. Iatrogenic Neonatal Esophageal Perforation: A European Multicentre Review on Management and Outcomes. Children. 2023;10(217):1-9. doi:10.3390/children10020217 google scholar CR - Filippi L, Pezzati M, Poggi C. Use of polyvinyl feeding tubes and iatrogenic pharyngo-esophageal perforation in very-low-birthweight infants. google scholar CR - Shah PS, Dunn MS, Shah VS. Esophageal Perforation in Preterm Neonates: Not an Innocent Bystander. 2003;39:697-699. google scholar CR - Gaber Elsayed M. Iatrogenic Esophageal Perforation in a Preterm Neonate Managed Conservatively. Academic Journal of Pediatrics & Neonatology. 2023;13(2):1-4 doi:10.19080/ajpn.2023.13.555911 google scholar CR - Brankov O, Shivachev H, Antonova D, Pahnev Y. Iatrogenic pharyngoesophageal perforation in the neonatal period-clues for conservative treatment. International Journal of Surgery and Medicine. 2017;3(2):107-110. doi:10.5455/ ijsm. google scholar CR - Thanhaeuser M, Lindtner-Kreindler C, Berger A, Haiden N. Conservative treatment of iatrogenic perforations caused by gastric tubes in extremely low birth weight infants. Early Hum Dev. 2019;137:1-5. doi:10.1016/ j.earlhumdev.2019.104836 google scholar CR - Hanafy EEDM, Ashebu SD, Naqeeb N Al, Nanda HB. Pericardial sac perforation: A rare complication of neonatal nasogastric tube feeding. Pediatr Radiol. 2006;36(10):1096-1098. doi:10.1007/s00247-006-0258-3 google scholar CR - Fogle RS; SWL; GEL. Perforation of the feeding tube into the right renal pelvis. The Journal of Pediatrics. 1978:122-124. google scholar CR - Mattar MS, Al-Alfy AA, Dahniya MH, Al-Marzouk MH. Urinary bladder perforation:an unusual complication of neonatal nasogastric tube feeding. Pediatr Radiol. 1997;27:858-859. google scholar CR - Elgendy MM, Othman H, Aly H. Esophageal perforation in very low birth weight infants. doi:10.1007/s00431-020-03894-z/Published google scholar CR - Panieri E, Millar AJW, Rode H, Brown RA, Cywes S. Iatrogenic Esophageal Perforation in Children: Patterns of Injury, Presentation, Management, and Outcome. Journal of Pediatric Surgery. 1996;31(7):890-895. google scholar CR - Kato Y, Hirata K, Oshima Y, Wada K, Dowling D, Schierholz E. Weight-based estimation of insertion length of the nasogastric tube in extremely low birth-weight infants. Advances in Neonatal Care. 2020;20(2):31-34. doi:10.1097/ ANC.0000000000000692 google scholar UR - https://doi.org/10.26650/jchild.2025.1573234 L1 - https://dergipark.org.tr/en/download/article-file/4313653 ER -