TY  - JOUR
T1  - Protective Evidence of Clarithromycin after Ischemic Cerebral Injury; an Experimental Study
AU  - Bıyık, Mehmet Orbay
AU  - Güvercin, Ali Rıza
AU  - Aktoklu, Mehmet
AU  - Arslan, Erhan
AU  - Kanat, Ayhan
AU  - Yazar, Uğur
AU  - Alver, Ahmet
PY  - 2025
DA  - February
Y2  - 2025
DO  - 10.19127/mbsjohs.1574851
JF  - Middle Black Sea Journal of Health Science
JO  - Mid Blac Sea J Health Sci
PB  - Ordu University
WT  - DergiPark
SN  - 2149-7796
SP  - 44
EP  - 56
VL  - 11
IS  - 1
LA  - en
AB  - Objective: Acute ischemic stroke is caused by a reduction in cerebral blood flow, leading to brain ischemic and subsequent cell death. The therapeutic options available for this condition are limited. The inflammatory response associated with the ischemic injury may influence the outcomes of ischemic stroke. Clarithromycin is a widely used antibiotic in medical practice. This study aimed to investigate the effect of clarithromycin on brain ischemic injury.Methods: In this study, 38 Sprague Dawley female rats were used and divided into four main groups: the pure control group, the ischemia group, the sham/control group, and the ischemic+claritromycin group. A temporary clip was placed in the bilateral carotid arteries of rats for 45 minutes. One group administered a dose of clarithromycin, and the tissue and blood samples of all four groups underwent biochemical evaluation. The results were subjected to statistical analysis.Results: The administration of clarithromycin to animals resulted in a reduction in malondialdehyde levels in brain tissues within the study group. Furthermore, Bederson's motor scores were observed to be higher in the clarithromycin-treated group in comparison to the ischemia group (p=0.092).Conclusion: A potential correlation exists between post-stroke infections and prognosis, suggesting that prophylactic antibiotic treatment may be beneficial. This study indicates that clarithromycin exerts a neuroprotective effect on cerebral ischemic injury following a stroke.
KW  - cerebral injury
KW  - clarithromycin
KW  - ischemia
KW  - neuroprotection
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UR  - https://doi.org/10.19127/mbsjohs.1574851
L1  - https://dergipark.org.tr/en/download/article-file/4320394
ER  -