TY - JOUR T1 - Tekrarlayan Gebelik Kayıplarının Etyopatogenezinde Oksidatif Stresin Rolü TT - The Role of Oxidative Stress in Recurrent Pregnancy Loss AU - Yiğenoğlu, Özgür AU - Uğur, Mete Gürol AU - Öztürk, Ebru AU - Balat, Özcan AU - Erel, Özcan PY - 2011 DA - August JF - Journal of Turgut Ozal Medical Center JO - J Turgut Ozal Med Cent PB - Inonu University WT - DergiPark SN - 1300-1744 SP - 236 EP - 239 VL - 18 IS - 4 LA - tr AB - Amaç: Tekrarlayan Gebelik Kaybı (TGK) etyopatogenezinde oksidatif stresin rolünün değerlendirilmesi. Gereç ve Yöntem: TGK izlenen 30 gebe ve sağlıklı 30 gebede Total Oksidan Seviye (TOS), Total Antioksidan Kapasite (TAK) ve Oksidatif Stres İndeksi (OSI) değerleri özgün, tam otomatik bir ölçüm yöntemi olan Erel metoduyla ölçülmüştür. Bulgular: TGK izlenen hasta grubunda TOS ve OSI değerleri istatistiksel olarak anlamlı ölçüde yüksek izlenirken (p=0.032, p=007), TAK değeri anlamlı ölçüde düşük olarak gözlenmiştir (p=0.013). Sonuç: TGK etypatogenezinde artmış oksidan seviye ve azalmış antioksidan kapasitenin rolü bulunmaktadır. Gelecekte TAK, TOS, OSI değerlerinin TGK prediksiyonundaki yerini ortaya koyabilecek yeni prospektif çalışmalara ihtiyaç vardır. Anahtar kelimeler: Tekrarlayan Gebelik Kaybı; Oksidatif Stres. KW - Tekrarlayan Gebelik Kaybı; Oksidatif Stres. N2 - Objective: To determine the role of oxidative stress in recurrent pregnancy loss by using using a novel automated method Material and Method: Thirty first trimester pregnant women with history of recurrent pregnancy loss (RPL) and 30 healthy pregnant women were enrolled in this prospective controlled study. The levels of total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) in maternal serum were measured by using the more recently designated Erel method. Results: We observed statistically significant increased TOS and OSI levels in patient group (p=0.032, p=0.007 respectively). We also demonstrated statistically significant decreased TAS level in pregnant women who had history of RPL (p=0.013). Conclusion: Our results support the concept that oksidative stress plays a central role in the etiopathogenesis of RPL. Further studies to evaluate the predictive role of TAS, TOS, OSI level by using Erel method are needed. Key words: Recurrent Pregnancy Loss, Oxidative Stress. CR - Wilcox AJ, Weinberg CR, O’Connor JF. Incidence of early loss of pregnancy. N Engl J Med 1988; 319: 189-94. CR - Gupta S, Agarwal A, Banerjee J, Alvarez JG. The role of oxidative stress in spontaneous abortion and recurrent pregnancy loss: a systematic review. Obstet Gynecol Surv 2007; 62: 335-47. CR - Halliwell B, Gutteridge JMC. Lipid peroxidation oxygen radicals, cell domage and antioxidant therapy. Lancet 1984; 23:1396-97. CR - Hochstein P, Atallah AS. The nature of oxidant and antioxidant systems in the inhibition of mutation and cancer. J Mut Res 1988; 202: 363-75. CR - Gupta S, Agarwal A, Banerjee J, Alvarez JG. The role of oxidative stress in spontaneous abortion and recurrent pregnancy loss: a systematic review. Obstet Gynecol Surv 2007; 62: 335-47. CR - Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. J Clin Biochem 2004; 37: 112-9. CR - Erel O. A new automated colorimetric method for measuring total oxidant status. J Clin Biochem 2005; 47: 119-129. CR - Ozturk E, Balat O, Acılmıs YG, Ozcan C, Pence S, Erel O. Measurement of the placental total antioxidant status in preeclamptic women using a novel automated method. J Obstet Gynaecol Res 2011; 37: 337-42. CR - Burton GJ, Jauniaux E. Placental oxidative stress: from miscarriage to preeclapmsia. J Soc Gynecol Investig 2004; 11: 342-52. CR - Harma M, Harma M. Defective placentation and resultant oxidative stress play a similar role in complete hydatidiform mole to that in preeclampsia and early pregnancy loss. Med Hypotheses 2006; 66: 100-2. CR - Poston L, Raijmakers MT. Trophoblast oxidative stress, antioxidants and pregnancy outcome–a review. Placenta 2004; 25: 72–8. CR - Safronova VG, Matveeva NK, Avkhacheva NV, Sidel'nikova VM, Van'ko LV, Sukhikh GT. Changes in regulation of oxidase activity of peripheral blood granulocytes in women with habitual abortions.Bull Exp Biol Med 2003; 136: 257-60. CR - Vural P, Akgül C, Yildirim A, Canbaz M. Antioxidant defence in recurrent abortion.Clin Chim Acta 2000; 295: 169-77. CR - Simşek M, Naziroğlu M, Simşek H, Cay M, Aksakal M, Kumru S. Blood plasma levels of lipoperoxides, glutathione peroxidase, beta carotene, vitamin A and E in women with habitual abortion. Cell Biochem Funct 1998; 16: 227-31. CR - El-Far M, El-Sayed IH, El-Motwally Ael-G, Hashem IA, Bakry N. Tumor necrosis factor-alpha and oxidant status are essential participating factors in unexplained recurrent spontaneous abortions.Clin Chem Lab Med 2007; 45: 879-83. CR - Schlesier K, Harwat M, Bohm V, Bitsch R. Assessment of antioxidant activity by using different invitro methods. Free Radic Res 2002; 36: 177-187. CR - Janaszewska A, Bartosz G. Assay of total antioxidant capacity: comparison off our methods as applied to human blood plasma. Scand J Clin Lab Invest 2002; 62: 231-23. UR - https://dergipark.org.tr/en/pub/totm/issue//157666 L1 - https://dergipark.org.tr/en/download/article-file/139237 ER -