TY - JOUR T1 - Amyotrofik Lateral Skleroz Olgularında Yoğun Bakım Tedavisi TT - Critical Care Management of Amyotrophic Lateral Sclerosis Cases AU - Toğal, Türkan AU - Aydoğan, Mustafa Said AU - Karahan, Kalender AU - Şener, Ali AU - Uçar, Muharrem AU - Ersoy, M Özcan PY - 2009 DA - April JF - Journal of Turgut Ozal Medical Center JO - J Turgut Ozal Med Cent PB - Inonu University WT - DergiPark SN - 1300-1744 SP - 131 EP - 134 VL - 16 IS - 2 LA - tr AB - Amyotrofik lateral skleroz (ALS) medülla spinalis, beyin sapı ve beynin motor korteksindeki motor nöronların ilerleyici dejeneratif bir hastalığıdır. Bilinç bozukluğu yapmadan yaygın kas güçsüzlüğü, yutma güçlüğü ve özellikle solunum güçlüğü yaratan bir hastalıktır. Bu yazıda ağır solunum yetmezliği ve pnömoniyle yoğun bakımda takip ve tedavi edilen üç ALS tanısı almış olgunun takip ve tedavisi sunulmuştur. Anahtar kelimeler: Amyotrofik Lateral Skleroz, Motor Nöron Hastalığı, Yoğun Bakım, Pnömoni KW - Amyotrofik Lateral Skleroz KW - Motor Nöron Hastalığı KW - Yoğun Bakım KW - Pnömoni N2 - Amyotrophic lateral sclerosis (ALS) is a progressive, neurodegenerative disease caused by the degeneration of motor neurons, including medulla spinalis, cerebellum and motor cortex of central nervous system that control voluntary muscle movement. The disease usually does not affect cognitive abilities, but makes muscle weakness, difficulty in swallowing and chewing especially breathing. Here in, we report the critical care management of three ALS case with pneumonia and severe respiratory distress. Key words: Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Critical Care, Pneumonia CR - Brown RH. Adult and juvenile Amyotrophic Lateral Sclerosis and related motor neuron diseases. Eds: Engel AG, Armstrong CF. In: Myology, McGraw-Hill; 2004:1865-88. CR - Sarchielli P, Pelliccioli GP, Tarducci R, et al. Magnetic resonance imaging and 1H-magnetic resonance spectroscopy in amyotrophic lateral sclerosis. Neuroradiology 2001;43: 189-197. CR - Beal MF. Mitochondria, free radicals, and neurodegeneration. Curr Opin Neurobiol. 1996;6(5):661-6. Review. CR - Bowen BC, Pattany PM, Bradley WG, et al. MR imaging and localized proton spectroscopy of the precentral gyrus in ALS. Am J Neuroradiol. 2000;21(4):647-58. CR - Bensimon G, Lacomblez L, Meininger V. A controlled trial of riluzole in amyotrophic lateral sclerosis. N Engl J Med. 19943;330(9):585-91. CR - Phukan J, Hardiman O. The management of amyotrophic lateral Sclerosis. Review. J Neurol 2009; 256:176–86 CR - 7.Lechtzin N; Rothstein J; Clawson L; Diette GB, Wiener CM. Amyotrophic lateral sclerosis: evaluation and treatment of respiratory impairment. Amyotroph Lateral Scler Other Motor Neuron Disord. 2002; 3(1):5-13 CR - Lo Coco DL, Marchese S, Pesco MC, La Bella V, Piccoli F, Lo Coco A. Noninvasive positive-pressure ventilation in ALS: Predictors of tolerance and survival. Neurology 2006; 67: 761-5 CR - Mackin GA. Optimizing care of patients with ALS. Steps to early detection and improved quality of life. Postgrad Med. 1999;105(4):143-6, 151-6. CR - Zuhal Karakurt. Evde mekanik ventilasyon. Yoğun Bakım Dergisi 2004;4: 145-50. UR - https://dergipark.org.tr/en/pub/totm/issue//157825 L1 - https://dergipark.org.tr/en/download/article-file/139396 ER -