TY  - JOUR
T1  - Sıçanlarda Diklofenak ile Oluşturulan Böbrek Toksisitesinde Rutin’in Etkilerinin Histopatolojik ve Biyokimyasal Olarak Araştırılması
TT  - Histopathological and Biochemical Investigation of the Effects of Rutin on Diclofenac-Induced Renal Toxicity in Rats
AU  - Oğuz Kabayel, Rabia
AU  - Akaras, Nurhan
AU  - Kandemir, Özge
AU  - Şimşek, Hasan
AU  - Kandemir, Fatih Mehmet
PY  - 2025
DA  - September
Y2  - 2025
DO  - 10.62425/jlasp.1581664
JF  - Laboratuvar Hayvanları Bilimi ve Uygulamaları Dergisi
JO  - Laboratuvar Hayvanları Bilimi ve Uygulamaları Dergisi
PB  - Ataturk University
WT  - DergiPark
SN  - 2791-8645
SP  - 81
EP  - 91
VL  - 5
IS  - 2
LA  - tr
AB  - Antiinflamatuar, antipiretik ve analjezik özellikleriyle bilinen nonsteroid antiinflamatuar ilaç (NSAID) kategorisinde yer alan diklofenak (DCL), uzun süreli kullanımı dokularda oksidatif stres ve inflamasyon artışına sebep olarak toksik etki oluşturur. Rutin (RUT), birçok bitkide doğal olarak bulunan anti-oksidan, anti-inflamatuar ve anti-apoptotik etkilere sahip bir flavanoid glikozidtir. Bu çalışmada, doğal bir antioksidan olan RUT’nin DCL kaynaklı böbrek doku hasarı üzerine etkilerinin araştırılması amaçlanmıştır. 28 adet wistar albino cinsi sıçan kontrol, DCL, RUT, DCL50 + RUT100 grupları olmak üzere 4 gruba ayrıldı. 4 gün boyunca 100 mg/kg RUT uygulaması oral yolla verilerek bununla birlikte 3. ve 4. günlerde 50 mg/kg dozda DCL uygulaması intraperitoneal yolla yapıldı. 5. günde böbrek dokuları alındı ve PCR (Polimeraz Zincir Reaksiyonu) yöntemi ile oksidatif stres, inflamasyon ve apoptotik belirteçlerin analizi ve dokuların histopatolojik analizi yapıldı. Böbrek dokularında DCL kaynaklı oksidatif stres, inflamasyon ve apoptoz parametrelerin düzeyleri kontrol grubuna göre artmıştır. RUT uygulamasıyla birlikte DCL bağlı tüm bu artış düzeylerinde azalmalar meydana gelmiştir. Böbrek dokularında DCL maruziyetinin sebep olduğu toksisiteye karşı RUT’nin potansiyel koruyucu etkiye sahip olduğu sonucuna varıldı.
KW  - Diklofenak
KW  - Nefrotoksisite
KW  - Rutin
KW  - Sıçan
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UR  - https://doi.org/10.62425/jlasp.1581664
L1  - https://dergipark.org.tr/en/download/article-file/4350089
ER  -