TY  - JOUR
T1  - Can Headache Be a Symptom of Celiac Disease?: A University Hospital Experience
TT  - Baş Ağrısı Çölyak Hastalığının Belirtisi Olabilir mi?: Bir Üniversite Hastanesi Tecrübesi
AU  - İpek, Rojan
AU  - Yavuz, Sibel
AU  - Kılıç, Fedli Emre
AU  - Karabel, Müsemma
AU  - Almış, Habip
PY  - 2025
DA  - January
Y2  - 2025
DO  - 10.31020/mutftd.1590672
JF  - Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi
PB  - Mersin University
WT  - DergiPark
SN  - 1309-8004
SP  - 323
EP  - 329
VL  - 15
IS  - 1
LA  - en
AB  - Aim: The purpose of this study was to determine the prevalence of Celiac disease in pediatric patients presenting with headache. However, little is known about the co-morbidity of Celiac disease and headache. To our knowledge, this is the first prospective pediatric study that systematically reviews this topic. Method: Two hundred forty four patients referred to the Pediatric neurology clinic of Adıyaman University Training and Research Hospital between January 2021 and November 2022 were examined. Gender, age, type of headache, Celiac serology, and other laboratory parameters of the cases meeting the inclusion criteria were recorded. Upper gastrointestinal endoscopy was performed on patients with positive Celiac serology. Patients whose results were compatible with Celiac disease were placed on a gluten-free diet. Results: The study group consisted of 202 patients, 123 girls (60.9%). The patients’ mean age was 12.67±3.524 years. Tension-type headache was determined in 121 (59.9%) of the patient group, and migraine type in 81 (40.1%). Celiac disease was detected in 5.4%. Vitamin B12 were 211±79.1 pg/ml, ferritin 19.5±13.9 ng/mL, and vitamin D 17.6±9.86 ng/ml (n=193). Interestingly, all patients who were diagnosed with Celiac disease reported that headache complaints decreased with the diet, However, no statistically significant correlation was found between any laboratory finding and headache type. Conclusion: Although it is still controversial whether headache is common in children with celiac disease, the results of our study showed that neurological symptoms improved after gluten-free diet in children presenting with headache and diagnosed with celiac disease. Celiac disease should be investigated in persistent headache despite pharmacological treatment.
KW  - Celiac
KW  - Child
KW  - Migraine
KW  - Tension
N2  - Amaç: Bu çalışmanın amacı, baş ağrısı ile başvuran çocuk hastalarda Çölyak Hastalığı prevalansını belirlemektir. Çölyak hastalığı ve baş ağrısı birlikteliği hakkında henüz çok az şey bilinmektedir. Bildiğimiz kadarıyla bu çalışma, bu konuyu sistematik olarak gözden geçiren ilk prospektif pediatrik çalışmadır.Metod: Ocak 2021 ve Kasım 2022 tarihleri arasında Adıyaman Üniversitesi Eğitim ve Araştırma Hastanesi Çocuk Nörolojisi kliniğine başvuran iki yüz kırk dört hasta incelendi. Çalışmaya dahil edilme kriterlerine uyan olguların cinsiyet, yaş, baş ağrısı tipi, Çölyak serolojisi ve diğer laboratuvar parametreleri kaydedildi. Çölyak serolojisi pozitif olan hastalara üst gastrointestinal endoskopi yapıldı. Sonuçları Çölyak Hastalığı ile uyumlu olan hastalara glutensiz diyet uygulandı.Bulgular: Çalışma grubu 123'ü kız (%60.9) olmak üzere 202 hastadan oluşmaktaydı. Hastaların yaş ortalaması 12.67±3.524 yıl idi. Hasta grubunun 121'inde (%59.9) gerilim tipi, 81'inde (%40.1) migren tipi baş ağrısı saptandı. Çölyak hastalığı %5,4 oranında tespit edildi. B12 vitamini 211±79,1 pg/ml, ferritin 19,5±13,9 ng/mL ve D vitamini 17,6±9,86 ng/ml idi (n=193). İlginç bir şekilde, Çölyak Hastalığı tanısı konan tüm hastalar diyetle birlikte baş ağrısı şikayetlerinin azaldığını bildirmiş, ancak herhangi bir laboratuvar bulgusu ile baş ağrısı tipi arasında istatistiksel olarak anlamlı bir korelasyon bulunmamıştır.Sonuç: Çölyak hastalığı olan çocuklarda baş ağrısının yaygın olup olmadığı hala tartışmalı olsa da, çalışmamızın sonuçları baş ağrısı ile başvuran ve çölyak hastalığı tanısı alan çocuklarda glutensiz diyet sonrası nörolojik semptomların düzeldiğini göstermiştir. Farmakolojik tedaviye rağmen inatçı baş ağrısında Çölyak hastalığı araştırılmalıdır.
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UR  - https://doi.org/10.31020/mutftd.1590672
L1  - https://dergipark.org.tr/en/download/article-file/4390833
ER  -