TY  - JOUR
T1  - Evaluation of single-dose inhalation of clarithromycin-loaded solid lipid nanoparticles in rat model
TT  - Sıçan modelinde klaritromisin yüklü katı lipid nanopartiküllerinin tek doz inhalasyonunun değerlendirilmesi
AU  - Cengiz, Mustafa
AU  - Bilici, Namık
AU  - Kulcanay Şahin, İlknur
AU  - Ersoy, Ömer
AU  - Özdemir, Nurullah
AU  - Ertekin, Rıfat
AU  - Ayhancı, Adnan
PY  - 2025
DA  - April
Y2  - 2025
DO  - 10.58605/bingolsaglik.1594508
JF  - Bingöl Üniversitesi Sağlık Dergisi
JO  - BÜSAD
PB  - Bingol University
WT  - DergiPark
SN  - 2717-7653
SP  - 31
EP  - 41
VL  - 6
IS  - 1
LA  - en
AB  - This study aimed to explore the effective utilization of clarithromycin (CLA) through the development of clarithromycin-loaded solid lipid nanoparticles (CLA-loaded SLN), designed for nebulizer-based delivery for the first time. Wistar albino rats were divided into seven groups (n=8) based on time points (0.5, 1, 2, 4, 12, 24 hours, and a control group). At the respective time points, lung tissues and blood samples were collected and analyzed for CLA concentrations using HPLC-MS/MS. The maximum serum concentration (Cmax) was 6.74 µg/mL, with average serum CLA concentrations of 5.06, 2.5, 2.18, 1.13, and 0.5 µg/mL across the groups. CLA was undetectable in the control group and in the serum of the last group. Using the linear trapezoidal method (LTM), the area under the curve (AUC 0-24) for serum CLA was calculated as 17.06 µg*h/mL. Significant differences (p
KW  - Clarithromycin
KW  - Clarithromycin aerosol
KW  - Drug exposure
KW  - Single-dose pharmacokinetics
KW  - Solid lipid nanoparticle inhaler drug
N2  - Bu çalışmanın amacı, ilk kez nebülizatör tabanlı uygulama için tasarlanmış klaritromisin yüklü katı lipit nanopartiküllerinin (CLA-SLN) geliştirilmesi yoluyla CLA’nın etkin kullanımını araştırmaktır. Wistar albino sıçanları zaman noktalarına (0.5, 1, 2, 4, 12, 24 saat ve kontrol grubu) göre yedi gruba (n = 8) ayrıldı. İlgili zaman noktalarında, akciğer dokuları ve kan örnekleri toplandı ve HPLC-MS/MS kullanılarak CLA konsantrasyonları açısından analiz edildi. Maksimum serum konsantrasyonu (Cmax) 6,74 µg/mL iken, gruplar arasında ortalama serum CLA konsantrasyonları sırasıyla 5,06, 2,5, 2,18, 1,13 ve 0,5 µg/mL idi. CLA, kontrol grubunda ve son grubun serumunda tespit edilemedi. Doğrusal trapezoidal yöntem kullanılarak, serum CLA için eğri altında kalan alan (AUC 0-24) 17,06 µg*h/mL olarak hesaplandı. Serum CLA seviyelerinde birkaç grup arasında anlamlı farklılıklar (p
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UR  - https://doi.org/10.58605/bingolsaglik.1594508
L1  - https://dergipark.org.tr/en/download/article-file/4408287
ER  -