TY  - JOUR
T1  - Dynamic Thiol / Disulfide Homeostasis In Patients With Nasal Polyps And The Effects Of Smoking On Homeostasis Parameters
AU  - Karalı, Elif
AU  - Bayatkara Yilmaz, Tugba
AU  - Yis, Özgür Mehmet
AU  - Güneş, Akif
PY  - 2025
DA  - April
Y2  - 2025
DO  - 10.47493/abantmedj.1594807
JF  - Abant Medical Journal
JO  - Abant Med J
PB  - Bolu Abant Izzet Baysal University
WT  - DergiPark
SN  - 1305-4392
SP  - 19
EP  - 27
VL  - 14
IS  - 1
LA  - en
AB  - AbstractObjective: The study aimed to determine the dynamic thiol/disulfide homeostasis for measuring oxidative stress and the impacts of smoking on these parameters in nasal polyps (NP) patients.Materials and methods: A total of forty NP patients and 36 healthy volunteers participated in the current study.  Participants were categorized into two groups: 20 smokers and 20 non-smokers. Erel and Neşelioğlu developed an automated method to analyze thiol-disulfide homeostasis parameters in samples of serum from the participants. Groups were compared. Each parameter related to thiol/disulfide homeostasis—native thiol (SH), total thiol (ToSH), disulfide (SS), SS/SH (%), SH/ToSH (%), and SS/ToSH (%)—was evaluated separately. Results: There were notable differences across the groups relating markers associated with thiol-disulfide balance. Total Thiol (ToSH) µmol/L (p=0.005), Native Thiol (SH) µmol/L (p=0.001), and SH/ToSH (%) levels were lower in patients with nasal polyps than the control group, and disulfide (SS) (p=0.001), SS/NT (%) (p=0.001), and SS/ToSH (%) levels were statistically significantly higher than the control group (p=0.001).Conclusion: In NP patients, thiol/disulfide homeostasis shifts towards disulfide formation because of native thiol oxidation. Also, parameters of Thiol/disulfide homeostasis can serve as new oxidative stress markers in nasal polyps.
KW  - Nasal polyp
KW  - Oxidative stress
KW  - Smoking
KW  - Thiol/disulfide homeostasis
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UR  - https://doi.org/10.47493/abantmedj.1594807
L1  - https://dergipark.org.tr/en/download/article-file/4409664
ER  -