TY  - JOUR
T1  - The Relationship Between Vaginal Microbiome and Infertility: A Descriptive Trend Analysis (1947-2024)
TT  - Vajinal mikrobiyom ve infertilite arasındaki ilişkinin bibliyometrik analizi
AU  - Erinmez, Mehmet
AU  - Koçer, İpek
PY  - 2025
DA  - May
Y2  - 2025
DO  - 10.47482/acmr.1599705
JF  - Archives of Current Medical Research
JO  - Arch Curr Med Res
PB  - 14 Mart Tıbbiyeliler Derneği
WT  - DergiPark
SN  - 2717-9788
SP  - 126
EP  - 134
VL  - 6
IS  - 2
LA  - en
AB  - Background: The menstrual cycle and gestational state, as well as other physiological factors, have a substantial impact on the vaginal microbiome, which aids in preventing infections caused by pathogenic microorganisms. Dysbiosis of the vaginal microbiome can cause infertility as well as adverse outcomes in pregnancy. The aim of this study is to examine the studies examining the relationship between vaginal microbiota and infertility in Scopus and WoS databases in terms of different variables and to compare them by revealing their bibliometric profiles.Methods: We conducted a bibliometric study to determine the scholarly papers published across all journals that addressed the relationship between the vaginal microbiome and infertility. Scopus and Web of Science (WoS) databases were accessed for all the published articles on vaginal microbiome and infertility. The number of publications by year, language, country, institute, author, journal, and impact factors (IF) are reported as bibliometric indicators.Results: Our findings indicate that the topic is much understudied; only 161 papers met the criteria set forth in our research. But, a striking increase was observed after 2020. The United States, China and Italy drew attention as the countries that contributed the most to the literature.Conclusion: Prospective and clinical studies on the mechanisms linking the vaginal microbiome of the female reproductive system to reproductive physiology may shed light on infertility treatment.
KW  - vaginal microbiome
KW  - dysbiosis
KW  - infertility
KW  - bibliometrci analysis
N2  - Giriş: Menstrual döngü, gebelik ve diğer fizyolojik faktörler, patojenik mikroorganizmaların neden olduğu enfeksiyonları önlemeye yardımcı olan vajinal mikrobiyom üzerinde önemli bir etkiye sahiptir. Vajinal mikrobiyomun disbiyozu infertiliteye ve gebelikte olumsuz sonuçlara neden olabilir. Yöntemler: Vajinal mikrobiyom ve infertilite arasındaki ilişkiyi ele alan tüm dergilerde yayınlanan akademik makaleleri belirlemek için bibliyometrik bir çalışma yürüttük. Vajinal mikrobiyom ve infertilite üzerine yayınlanan tüm makaleler için Scopus ve Web of Science (WoS) veri tabanlarına erişildi. Yıl, dil, ülke, enstitü, yazar, dergi ve etki faktörleri (IF) bazında yayın sayıları bibliyometrik göstergeler olarak raporlandı. Bulgular: Bulgularımız, konunun çok az çalışıldığını gösteriyor; sadece 154 makale araştırmamızda belirtilen kriterleri karşıladı. Ancak, 2020'den sonra çarpıcı bir artış gözlemlendi. Amerika Birleşik Devletleri, Çin ve İtalya, literatüre en çok katkıda bulunan ülkeler olarak dikkat çekti. Sonuç: Kadın üreme sisteminin vajinal mikrobiyomunun üreme fizyolojisine bağlanma mekanizmaları üzerine yapılacak prospektif ve klinik çalışmalar, infertilite tedavisine ışık tutabilir.
CR  - Ursell LK, Metcalf JL, Parfrey LW, Knight R. Defining the human microbiome. Nutr Rev. 2012;70(Suppl 1):38–44.
CR  - Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI. The Human Microbiome Project. Nature. 2007;449(7164):804–10.
CR  - Cho I, Blaser MJ. The human microbiome: at the interface of health and disease. Nat Rev Genet. 2012;13(4):260–70.
CR  - Moreno I, Simon C. Deciphering the effect of reproductive tract microbiota on human reproduction. Reprod Med Biol. 2018;18(1):40–50.
CR  - Ma B, Forney LJ, Ravel J. Vaginal microbiome: rethinking health and disease. Annu Rev Microbiol. 2012; 66:371–89.
CR  - Kroon SJ, Ravel J, Huston WM. Cervicovaginal microbiota, women's health, and reproductive outcomes. Fertil Steril. 2018;110(3):327–36.
CR  - Gupta S, Kakkar V, Bhushan I. Crosstalk between Vaginal Microbiome and Female Health: A review. Microb Pathog. 2019; 136:103696.
CR  - Romero R, Hassan SS, Gajer P, Tarca AL, Fadrosh DW, Nikita L, et al. The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women. Microbiome. 2014;2(1):4.
CR  - Gajer P, Brotman RM, Bai G, Sakamoto J, Schütte UM, Zhong X, et al. Temporal dynamics of the human vaginal microbiota. Sci Transl Med. 2012;4(132):132ra52.
CR  - DiGiulio DB, Callahan BJ, McMurdie PJ, Costello EK, Lyell DJ, Robaczewska A, et al. Temporal and spatial variation of the human microbiota during pregnancy. Proc Natl Acad Sci U S A. 2015;112(35):11060–5.
CR  - Saraf VS, Sheikh SA, Ahmad A, Gillevet PM, Bokhari H, Javed S. Vaginal microbiome: normalcy vs dysbiosis. Arch Microbiol. 2021;203(7):3793–802.
CR  - Spandorfer SD, Neuer A, Giraldo PC, Rosenwaks Z, Witkin SS. Relationship of abnormal vaginal flora, proinflammatory cytokines and idiopathic infertility in women undergoing IVF. J Reprod Med. 2001;46(9):806–10.
CR  - Shuaib W, Khan MS, Shahid H, Valdes EA, Alweis R. Bibliometric analysis of the top 100 cited cardiovascular articles. Am J Cardiol. 2015;115(7):972–81.
CR  - Luukkonen T. Bibliometrics and evaluation of research performance. Ann Med. 1990;22(3):145–50.
CR  - Chen C, Song X, Wei W, et al. The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases. Nat Commun. 2017; 8:875.
CR  - Moreno I, Codoñer FM, Vilella F, Valbuena D, Martinez-Blanch JF, Jimenez-Almazán J, et al. Evidence that the endometrial microbiota has an effect on implantation success or failure. Am J Obstet Gynecol. 2016;215(6):684–703.
CR  - Smith SB, Ravel J. The vaginal microbiota, host defence and reproductive physiology. J Physiol. 2017;595(2):451–63.
CR  - Haahr T, Jensen JS, Thomsen L, Duus L, Rygaard K, Humaidan P. Abnormal vaginal microbiota may be associated with poor reproductive outcomes: a prospective study in IVF patients. Hum Reprod. 2016;31(4):795–803.
CR  - Tsevat DG, Wiesenfeld HC, Parks C, Peipert JF. Sexually transmitted diseases and infertility. Am J Obstet Gynecol. 2017;216(1):1–9.
CR  - Yarbrough VL, Winkle S, Herbst-Kralovetz MM. Antimicrobial peptides in the female reproductive tract: a critical component of the mucosal immune barrier with physiological and clinical implications. Hum Reprod Update. 2015;21(3):353–77.
CR  - van Oostrum N, De Sutter P, Meys J, Verstraelen H. Risks associated with bacterial vaginosis in infertility patients: a systematic review and meta-analysis. Hum Reprod. 2013;28(7):1809–15.
CR  - Hyman RW, Herndon CN, Jiang H, Palm C, Fukushima M, Bernstein D, et al. The dynamics of the vaginal microbiome during infertility therapy with in vitro fertilization-embryo transfer. J Assist Reprod Genet. 2012;29(2):105–15.
CR  - Kyono K, Hashimoto T, Nagai Y, Sakuraba Y. Analysis of endometrial microbiota by 16S ribosomal RNA gene sequencing among infertile patients: a single-center pilot study. Reprod Med Biol. 2018;17(3):297–306.
CR  - Sirota I, Zarek SM, Segars JH. Potential influence of the microbiome on infertility and assisted reproductive technology. Semin Reprod Med. 2014;32(1):35–42.
CR  - Baker JM, Chase DM, Herbst-Kralovetz MM. Uterine Microbiota: Residents, Tourists, or Invaders? Front Immunol. 2018; 9:208.
CR  - Hou D, Zhou X, Zhong X, Settles ML, Herring J, Wang L, Abdo Z, Forney LJ, Xu C. Microbiota of the seminal fluid from healthy and infertile men. Fertil Steril. 2013;100(5):1261-9.
CR  - Salliss ME, Farland LV, Mahnert ND, Herbst-Kralovetz MM. The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain. Hum Reprod Update. 2021;28(1):92-131.
UR  - https://doi.org/10.47482/acmr.1599705
L1  - https://dergipark.org.tr/en/download/article-file/4432299
ER  -