TY - JOUR T1 - Impact of Prognostic Nutritional Index on Clinical Outcomes in Hereditary Angioedema: A single center experience TT - Herediter Anjiyoödemde Prognostik Nutrisyonel İndeksin Klinik Sonuçlar Üzerine Etkisi: Tek Merkez Deneyimi AU - Gerek, Mehmet Emin AU - Çölkesen, Fatih AU - Önalan, Tuğba AU - Akkuş, Fatma Arzu AU - Evcen, Recep AU - Kılınç, Mehmet AU - Kahraman, Selim AU - Arslan, Şevket PY - 2025 DA - April Y2 - 2025 DO - 10.54005/geneltip.1600277 JF - Genel Tıp Dergisi JO - Genel Tıp Derg PB - Selcuk University WT - DergiPark SN - 2602-3741 SP - 285 EP - 292 VL - 35 IS - 2 LA - en AB - AbstractBackground/Aims: Hereditary angioedema (HAE) is a rare genetic disorder (prevalence approximately 1:50,000) marked by recurrent episodes of severe swelling due to a deficiency in the C1 inhibitor (C1-INH) protein, affecting the complement and contact systems. This study aims to evaluate the impact of the Prognostic Nutritional Index (PNI) on clinical outcomes in HAE patients.Methods: A single-center retrospective cohort of 60 patients was analyzed. Clinical characteristics and PNI were assessed, calculated using the formula: [Serum Albumin (g/L)] + [5 × Peripheral Blood Lymphocyte Count (×10⁹/L)]. Patients were stratified into low and high PNI groups based on a cut-off value of 51.725, derived from receiver operating characteristic (ROC) curve analysis (AUC = 0.902, p < 0.001). Statistical significance was set at p < 0.05.Results: Low PNI was significantly associated with increased attack frequency (p < 0.001), extended diagnostic delays (p = 0.022), and greater laryngeal (p = 0.003) and gastrointestinal involvement (p = 0.005). Furthermore, low PNI was negatively correlated with monthly attack frequency (Spearman’s rho = -0.653, p < 0.001) and positively correlated with C1-INH function (Spearman’s rho = 0.408, p = 0.001).Conclusions: These findings underscore the importance of incorporating nutritional evaluations into HAE management, as poor nutritional status may exacerbate disease severity. Further prospective studies are needed to validate these associations and explore nutritional interventions as a complementary strategy in HAE treatment. KW - Hereditary angioedema (HAE) KW - Prognostic Nutritional Index (PNI) KW - Clinical outcomes KW - Nutritional status KW - Attack frequency N2 - ÖzetGiriş/Amaç: Herediter anjiyoödem (HAE), C1 inhibitör (C1-INH) protein eksikliğine bağlı olarak kompleman ve kontakt sistemlerini etkileyen, yaklaşık 1:50.000 prevalans ile seyreden nadir bir genetik hastalıktır. Hastalık, tekrarlayan ciddi şişlik atakları ile karakterizedir. 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UR - https://doi.org/10.54005/geneltip.1600277 L1 - https://dergipark.org.tr/en/download/article-file/4435071 ER -