TY - JOUR T1 - Innovative Nutraceutical Approach in the Treatment of Chronic Gingivostomatitis: Insights Gained from the Case AU - Özalp, Tahir AU - Erdoğan, Songül AU - Erdoğan, Hasan AU - Ural, Kerem PY - 2025 DA - June Y2 - 2025 DO - 10.5281/zenodo.15755450 JF - Journal of Veterinary Case Reports JO - J Vet Case Rep PB - Ataturk University WT - DergiPark SN - 2792-064X SP - 10 EP - 14 VL - 5 IS - 1 LA - en AB - A nine-year-old female domestic shorthair cat presented with lethargy, anorexia, recurrent severe oral lesions, and oral pain. The cat was diagnosed with FCGS associated with FIV infection. Management was followed with a nutraceutical supplement including primarily iodine and arginine. Over a 2.5-month period, significant clinical improvements were observed, including resolution of oral lesions, increased appetite, and improved activity levels. This case report highlighted the potential role of nutraceuticals as a treatment regime for managing FCGS in FIV-positive cats, particularly in cases resistant to traditional treatments. KW - Arginine KW - Cat KW - Iodine KW - Stomatitis CR - Soltero-Rivera M, Goldschmidt S, Arzi B. Feline chronic gingivostomatitis current concepts in clinical management. J Feline Med Surg. 2023;25(8):1098612X231186834. CR - Older CE, Gomes MDOS, Hoffmann AR, et al. Influence of the FIV status and chronic gingivitis on feline oral microbiota. Pathogens. 2020;9(5):383. CR - Belgard S, Truyen U, Thibault JC, Sauter-Louis C, Hartmann K. Relevance of feline calicivirus, feline immunodeficiency virus, feline leukemia virus, feline herpesvirus and Bartonella henselae in cats with chronic gingivostomatitis. Berl Munch Tierarztl Wochenschr. 2010;123(9-10):369-376. CR - Ahmad AM, Ali OJ, Marif HF, Ali BA. Therapeutic Management of Chronic Gingivostomatitis In Cats. A Comprehensive Review. Basrah J Vet Res. 2024;23(3):156-169. CR - Bellei E, Dalla F, Masetti L, Pisoni L, Joechler M. Surgical therapy in chronic feline gingivostomatitis (FCGS). Vet Res Commun. 2008;32:231-234. CR - Szondi DC, Wong JK, Vardy LA, Cruickshank SM. Arginase signalling as a key player in chronic wound pathophysiology and healing. Front Mol Biosci. 2021;8:773866. CR - Paßlack N, Kohn B, Zentek J. Effects of arginine and ornithine supplementation to a high-protein diet on selected cellular immune variables in adult cats. J Vet Intern Med. 2020;34(2):852-856. CR - Druet I, Hennet P. Relationship between feline calicivirus load, oral lesions, and outcome in feline chronic gingivostomatitis (caudal stomatitis): retrospective study in 104 cats. Front Vet Sci. 2017;4:209. CR - Matsumoto H, Teshima T, Iizuka Y, Sakusabe A, Takahashi D, Amimoto A, Koyama H. Evaluation of the efficacy of the subcutaneous low recombinant feline interferon-omega administration protocol for feline chronic gingivitis-stomatitis in feline calicivirus-positive cats. Res Vet Sci. 2018;121:53-58. CR - 1Johnston, N. (2012). An updated approach to chronic feline gingivitis stomatitis syndrome. Veterinary Practice, 44, 34-38. CR - 1Mamo JC, Naissides M. Could iodine be effective in the treatment of human immunodeficiency virus and AIDS-associated opportunistic infections? Int J Infect Dis. 2005;9(5):292-293. CR - 1Bingen A, Nonnenmacher H, Bastien-Valle M, Martin JP. Tissues rich in macrophagic cells are the major sites of feline immunodeficiency virus uptake after intravenous inoculation into cats. Microbes Infect. 2002;4(8):795-803. CR - 1Vahlenkamp TW, Tompkins MB, Tompkins WA. Feline immunodeficiency virus infection phenotypically and functionally activates immunosuppressive CD4+ CD25+ T regulatory cells. J Immunol. 2004;172(8):4752-4761. CR - Cloke TE, Garvey L, Choi BS, et al. Increased level of arginase activity correlates with disease severity in HIV-seropositive patients. J Infect Dis. 2010;202(3):374-385. CR - Paßlack N, Kohn B, Zentek J. Effects of arginine and ornithine supplementation to a high-protein diet on selected cellular immune variables in adult cats. J Vet Intern Med. 2020;34(2):852-856. UR - https://doi.org/10.5281/zenodo.15755450 L1 - https://dergipark.org.tr/en/download/article-file/4436237 ER -