@article{article_1602748, title={Comorbidity results of an obesity center}, journal={The European Research Journal}, volume={11}, pages={378–386}, year={2025}, DOI={10.18621/eurj.1602748}, author={Tuna, Müjgan and Kırlak, Şenay and Akın, Seydahmet and Çakır Madenci, Özlem}, keywords={Obesity, insulin resistance, metabolic parameters, diabetes mellitus, body mass index}, abstract={<p> <b>Objectives: </b> Obesity is linked to numerous severe health conditions, including type 2 diabetes mellitus, heart disease, hypertension, and stroke. This study aimed to compare metabolic parameters and anthropometric measurements between male and female patients with obesity to identify gender-based differences in obesity-related health markers. </p> <p> <b>Methods: </b> This prospective study enrolled 393 obese patients (52 male, 341 female) from an outpatient clinic. After an overnight fast (8-10 hours), blood samples were collected to assess a range of parameters: complete blood count, fasting blood glucose, insulin, Hemoglobin A1c (HbA1c), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Thyroid-stimulating hormone (TSH), total cholesterol, triglycerides, Low-density lipoprotein (LDL), High-density lipoprotein (HDL), 25-hydroxy vitamin D3 (25OHD3), ferritin, iron, and vitamin B12. Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and Body Mass Index (BMI) were calculated, while soft lean mass (SLM) and percent body fat (PBF) were also analyzed. </p> <p> <b>Results: </b> Males with obesity had significantly higher levels of insulin, HOMA-IR, 25OHD3, ferritin, iron, hemoglobin, hematocrit, urea, and ALT compared to females (P<0.05 for all). Conversely, males had lower HDL and platelet levels (P<0.05). The prevalence of thyroid disease was significantly higher in females (P=0.027). </p> <p> <b>Conclusions: </b> Thyroid disease prevalence was significantly higher in females compared to males. Additionally, metabolic parameters such as insulin, HOMA-IR, and urea were elevated in females, while HDL and platelet levels were lower in males. </p>}, number={2}, publisher={Prusa Medical Publishing}