TY  - JOUR
T1  - Comorbidity results of an obesity center
AU  - Tuna, Müjgan
AU  - Kırlak, Şenay
AU  - Akın, Seydahmet
AU  - Çakır Madenci, Özlem
PY  - 2025
DA  - March
Y2  - 2025
DO  - 10.18621/eurj.1602748
JF  - The European Research Journal
JO  - Eur Res J
PB  - Prusa Medical Publishing
WT  - DergiPark
SN  - 2149-3189
SP  - 378
EP  - 386
VL  - 11
IS  - 2
LA  - en
AB  - Objectives:  Obesity is linked to numerous severe health conditions, including type 2 diabetes mellitus, heart disease, hypertension, and stroke. This study aimed to compare metabolic parameters and anthropometric measurements between male and female patients with obesity to identify gender-based differences in obesity-related health markers.Methods:  This prospective study enrolled 393 obese patients (52 male, 341 female) from an outpatient clinic. After an overnight fast (8-10 hours), blood samples were collected to assess a range of parameters: complete blood count, fasting blood glucose, insulin, Hemoglobin A1c (HbA1c), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Thyroid-stimulating hormone (TSH), total cholesterol, triglycerides, Low-density lipoprotein (LDL), High-density lipoprotein (HDL), 25-hydroxy vitamin D3 (25OHD3), ferritin, iron, and vitamin B12. Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and Body Mass Index (BMI) were calculated, while soft lean mass (SLM) and percent body fat (PBF) were also analyzed. Results:  Males with obesity had significantly higher levels of insulin, HOMA-IR, 25OHD3, ferritin, iron, hemoglobin, hematocrit, urea, and ALT compared to females (P<0.05 for all). Conversely, males had lower HDL and platelet levels (P<0.05). The prevalence of thyroid disease was significantly higher in females (P=0.027).Conclusions:  Thyroid disease prevalence was significantly higher in females compared to males. Additionally, metabolic parameters such as insulin, HOMA-IR, and urea were elevated in females, while HDL and platelet levels were lower in males.
KW  - Obesity
KW  - insulin resistance
KW  - metabolic parameters
KW  - diabetes mellitus
KW  - body mass index
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UR  - https://doi.org/10.18621/eurj.1602748
L1  - https://dergipark.org.tr/en/download/article-file/4446017
ER  -