@article{article_1603500, title={Antithrombotic Therapy Does Not Jeopardize Emergency Percutaneous Nephrostomy}, journal={The New Journal of Urology}, volume={20}, pages={13–20}, year={2025}, DOI={10.33719/nju1603500}, author={Kılıç, Şahin and Alparslan, Ahmet Sukru and Kölükçü, Engin and Özsoy, Çağatay and Şambel, Murat and Taş, Selim}, keywords={Antiaggregant, Anticoagulant, Emphysematous pyelonephritis, Percutaneous nephrostomy, Pyelonephrosis, Urological emergency.}, abstract={Objective: This study aims to evaluate the outcomes of patients on antithrombotic (antiaggregant and anticoagulant) therapy who underwent emergency percutaneous nephrostomy (PN) for complicated upper urinary tract infection.
Materials and Methods: Data from consecutive patients who underwent emergency PN from January 2014 to October 2024 were retrospectively reviewed. A total of 34 patients on antithrombotic treatment (Group 1) and 35 control group patients (Group 2) without bleeding disorders or antithrombotic treatment were included. Demographics, PN indications, pre- and post-procedural haematological, biochemical, and microbiological parameters and complications were analysed.
Results: The mean age was 67.82±9.73 in group 1 and 63.06±11.58 in group 2 (p=0.006). Sex distribution and indications for PN were comparable between groups. There was no significant difference in emergency PN indications, hydronephrosis grades, and PN placement sides. The most common antithrombotic in group 1 was warfarin (44.1 %). Escherichia coli was the most frequently isolated bacteria in both groups (55.9% vs. 48.6 % for groups 1 and 2, respectively). No major complication was observed in both groups after PN procedure. Blood replacement was performed in 4 and 3 patients in groups 1 and 2, respectively. Post-procedure mean Hg levels were similar in both groups (9.53 ±1.39 vs. 9.98 ±1.18 for groups 1 and 2, respectively). No difference in median hospital stay was observed between the groups.
Conclusion: Antithrombotic drugs pose potential bleeding risks during PN placement. This is the first study in the literature on PN placement in patients on antithrombotic therapy and it indicates that the procedure can be performed with low complication rates in patients on antithrombotic therapy.}, number={1}, publisher={Ali İhsan TAŞÇI}, organization={This study was not supported by any funding.}