@article{article_1604019, title={Protective effect of peroral capsaicin administration in ethanol-induced gastric ulcer model in rats.}, journal={Ege Tıp Dergisi}, volume={64}, pages={98–106}, year={2025}, DOI={10.19161/etd.1604019}, author={Keçeci, Mete and Akpolat Ferah, Meryem and Khoshvaghti, Habib and Cengil, Osman}, keywords={Ethanol, ulcer, capsaicin, caspase 3, NF-κB}, abstract={Aim: Capsaicin is a compound that possesses antioxidants and anti-inflammatory properties, and it is found in almost all bitter fruits. The objective of our study was to investigate the protective effect of capsaicin in an ethanolic ulcer model.
Materials and Methods: The male Wistar albino rats were divided into four groups, comprising a control group and three experimental groups (n=8). The control group (C) administered a single dose of distilled water subcutaneously. The Capsaicin (CAP) group was administered a single dose of 1 mg/kg CAP via gavage. The ulcer group administered a single dose of 1ml absolute alcohol via gavage, 30 minutes following the administration of a single dose of distilled water via gavage. The U+CAP group administered 1ml of absolute alcohol 30 minutes following the administration of 1 mg/kg CAP. Macroscopic and microscopic ulcer scores, as well as mucosal barrier integrity, were evaluated in the gastric tissues that had been removed. The levels of total oxidant status (TOS) and total antioxidant status (TAS) were determined in the tissue samples, and an oxidative stress index (OSI) was calculated. Results: In comparison to the U group, the macroscopic and microscopic mucosal lesions, TOS, OSI levels and IL-1, TNF-α, NFκB and Caspase 3 expressions were found to be decreased in the U+CAP group, while TAS levels were observed to be increased.
Conclusion: The results of the study demonstrated that capsaicin protects mucosal integrity through its antioxidant, anti-inflammatory and anti-apoptotic properties in the ethanol-induced gastric ulcer model.}, number={1}, publisher={Ege University}, organization={This study was supported by Zonguldak Bülent Ecevit University Scientific Research Projects Coordination (2020-98210206-01).}