TY  - JOUR
T1  - Matairesinol induced antiproliferative effects via  mitochondrial dysfunction in HepG2 cells
AU  - Arzuk, Ege
AU  - Ergüç, Ali
AU  - Demir, Serhat
AU  - Ünver Somer, Nehir
AU  - Tan, İclal
AU  - Atış, Ecrin
PY  - 2025
DA  - July
Y2  - 2024
JF  - Journal of Research in Pharmacy
JO  - J. Res. Pharm.
PB  - Marmara University
WT  - DergiPark
SN  - 2630-6344
SP  - 2001
EP  - 2007
VL  - 28
IS  - 6
LA  - en
AB  - Hepatocellular carcinoma is one of the most severe and life-threatening types of cancer. The conventional treatment of hepatoma has significant challenges due to the adverse effects of chemotherapy, leading to treatment failure and decreased survival. Therefore, developing and investigating novel and safer anticancer drugs and establishing more effective therapeutic regimens is a crucial field of research. The Haplophyllum megalanthum-derived compound matairesinol has demonstrated antiproliferative and antitumor activity against various types of cancer, including pancreatic, breast, and prostate cancer. However, the potential effects of matairesinol on liver cancer, as well as the underlying molecular mechanisms associated with its anticancer activity, have yet to be thoroughly elucidated. In the current study, we demonstrated that matairesinol inhibited the viability of human hepatoma cells in a dose-dependent manner. Besides, at IC50 and higher doses, matairesinol induced oxidative stress and impaired mitochondrial membrane potential and ATP levels, two evidence of mitochondrial damage. Moreover, matairesinol exposure led to significant caspase-3 activation, a hallmark of apoptosis. These results indicate that mitochondrial damage and caspase-3 activation may contribute to the cytotoxic effect of matairesinol on liver cancer cells.
KW  - Matairesinol
KW  - liver cancer
KW  - mitochondria
KW  - caspase-3
KW  - anticancer effect
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UR  - https://dergipark.org.tr/en/pub/jrespharm/issue//1607847
L1  - https://dergipark.org.tr/en/download/article-file/4469510
ER  -