@article{article_1608129, title={The role of biochemical markers in predicting pre-eclampsia}, journal={Ege Tıp Dergisi}, volume={64}, pages={324–329}, year={2025}, DOI={10.19161/etd.1608129}, url={https://izlik.org/JA92RF75CX}, author={Atlıhan, Ufuk and Ertan, Begüm and Peker, Mehmet Emre and Ata, Can and Yavuz, Onur and Avşar, Hüseyin Aytuğ and İleri, Alper and Bıldacı, Tevfik Berk and Erkılınç, Selçuk}, keywords={NLR, PLR, Pregnancy, SII, SIRI, Preeclampsia}, abstract={Aim: The aim of our study was to evaluate the role of biochemical markers in predicting preeclampsia. Materials and Methods: 7240 women whose pregnancy follow-ups and deliveries were carried out by us between March 2018 and March 2024 were retrospectively screened. Patients in the study group consisted of 102 women diagnosed with preeclampsia at <34 weeks of gestation, and patients in the control group consisted of 118 women who gave birth at ≥37 weeks of gestation. Demographic characteristics and obstetric and biochemical outcomes of the two groups were compared with each other.
Results: The body mass index (BMI) value was significantly higher in the preeclampsia group compared with the controls group (p=0.016). The birth weight value was significantly lower in the preeclampsia group compared with the controls group (p<0.001). The gestational week at delivery was significantly lower in the preeclampsia group compared with the controls group (p<0.001). Lymphocyte and platelet counts were significantly lower in the preeclampsia group compared with the controls group (p<0.001 and p<0.001, respectively). NLR and SII value were significantly higher in the preeclampsia group compared with the controls group (p=0.022, p<0.001, respectively).
Conclusion: Our study reveals important clinical and laboratory differences in preeclamptic pregnancies. Increased inflammatory markers were found to be a feature of preeclamptic pregnancies and are consistent with the existing literature. Our findings can be used to determine early diagnosis and comprehensive management strategies to minimize the risks associated with preeclampsia.}, number={2}