@article{article_1610470, title={Investigation of Novel Hematological Index Variations in Cats Naturally Infected with Feline Panleukopenia Virus}, journal={Kocatepe Veterinary Journal}, volume={18}, pages={52–60}, year={2025}, author={Aydın, Ömer}, keywords={Feline panleukopenia virus, Lymphocyte to monocyte ratio, Neutrophil to lymphocyte ratio, Systemic immune-inflammation index, Systemic inflammatory response index}, abstract={Feline panleukopenia is a viral infection that impacts cats of all age groups, with particularly high mortality rates observed around the age of 3 months. The disease spreads through the fecal-oral transmission route. This study aims to evaluate the levels of various inflammatory hematologic indices—specifically, the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic inflammation response index (SIRI), and systemic immune-inflammatory index (SII)—in cats naturally exposed to Feline Panleukopenia Virus (FPV), and to assess the potential of these indices as markers of inflammation. Two groups were included in the study: a control group consisting of 20 healthy cats and an experimental group consisting of 40 cats showing symptoms of anorexia, vomiting, and/or diarrhea, diagnosed with FPV using a rapid test kit. All cats in both groups were between 0 and 3 months old and represented a variety of breeds and genders. No significant differences were found between the groups for the NLR and LMR values (with p-values of 0.054 and 0.627, respectively). However, the PLR was significantly higher in the FPV-infected group compared to the control group (p<0.001). In contrast, the SIRI (p<0.001) and SII (p=0.002) values were notably lower in the FPV-infected cats. In conclusion, this study revealed that there were significant differences in haematological indices between the two groups and PLR, SIRI and SII were important markers to reflect the inflammatory status in FPV infection.}, number={1}, publisher={Afyon Kocatepe University}