TY - JOUR T1 - Importance of B-type Natriuretic Peptide (BNP) Analysis and Hemogram Evaluation in Cats wıth Pericardial Effusion Detected on Echocardiography AU - Öcal, Naci AU - Oflaz, Saadet PY - 2025 DA - May Y2 - 2025 DO - 10.24998/maeusabed.1610651 JF - Mehmet Akif Ersoy University Journal of Health Sciences Institute PB - Burdur Mehmet Akif Ersoy University WT - DergiPark SN - 2148-2837 SP - 13 EP - 21 VL - 13 IS - 1 LA - en AB - This study aimed to measure plasma NT-proBNP levels and hemogram parameters in 20 cats diagnosed with pericardial effusion by echocardiographic examination and to determine whether NT-proBNP could be used as a cardiac biomarker in the confirmation of pericardial effusion.The study was conducted on 40 cats, consisting of a patient group of 20 cats of different ages, breeds and genders diagnosed with pericardial effusion by echocardiographic examination at the Cat Hospital Animal Hospital, and a control group of 20 healthy cats in terms of heart diseases. Blood samples were taken from the patient group and the control group cats for total blood count and NT-proBNP analysis. NT-proBNP values were determined from the prepared serum samples using the Vcheck200 – BIONOTE device. Total blood count was performed using the IDEXX ProCyte Dx TM Hematology Analyzer. After pericardial effusion was detected in echocardiography examination, M-mode measurement parameters such as left ventricular free wall thickness (LVPW) in systole and diastole, interventricular septum wall thickness (IVSD) in systole and diastole, end-diastole and end-systole left ventricular internal diameter (LVID), left atrium internal diameter (LA), aortic diameter (AO), LA/AO ratio, left ventricular ejection fraction (EF), and fractional shortening (FS) were evaluated.In conclusion, in the statistical analysis of the data obtained in this study, while no statistically significant difference was observed between the groups in total blood count, it was determined that NT-proBNP increased significantly in cats with pericardial effusion. Therefore, it was concluded that NT-proBNP can be used as a cardiac biomarker in the diagnosis of pericardial effusion in cats. KW - BNP KW - cat KW - echocardiography KW - pericardial effusion CR - Boeykens, F., Abitbol, M., Anderson, H., Dargar, T., Ferrari, P., Fox, P.R., Hayward, J.J., Häggström, J., Davison, S., Kittleson, M. D., van Steenbeek, F., Ljungvall, I., Lyons, L.A., Longeri, M., Ohlsson, Å., Peelman, L., Dufaure de Citres, C., Smets, P., Turba, M.E., & Broeckx, B.J.G. (2024). Classification of feline hypertrophic cardiomyopathy-associated gene variants according to the American College of Medical Genetics and Genomics guidelines. Front. Vet. Sci, 11. https://doi.org/10.3389/fvets.2024.1327081 CR - Chomel, B.B, Wey, A.C, Kasten R.W, Stacy, B.A., & Labelle, P. (2003). Fatal case of endocarditis associated with Bartonella henselae type I infection in a domestic cat. J Clin Microbiol, 41: 5337e5339. CR - Ciaravolo, S.V., Dobson, E., Liffman, R., & Stickney, A. ( 2022). Severe pericardial effusion in a cat with peritoneopericardial diaphragmatic hernia and incarcerated hepatic sarcoma. J. Feline Med. Surg. Open Rep., 8(2), 20551169221121926. CR - Coakes, S.J., Steed, L.G., & Ong, C. (2009). SPSS 16.0 for Windows: analysis. John Wiley and Sons Australia, Chichester. CR - Cote E., MacDonald K.A., Meurs K.M., & Sleeper, M.M. (2011). Feline Cardiology. (1st ed.). Oxford: Wiley-Blackwell, 22: 341-349. CR - Davidson, B.J., Paling, A.C., Lahmers, S.L., & Nelson, O.L. (2008). Disease Association and Clinical Assessment of Feline Pericardial Effusion. J. Am. Anim. Hospt. Assoc., 44(1), 5–9. https://doi.org/10.5326/0440005. CR - Fox, P.R., Oyama, M.A., Reynolds, C., Rush, J.E., DeFrancesco, T.C., Keene, B.W., Atkins, C.E., MacDonald, K.A., Schober, K.E., Bonagura, J.D., Stepien, R.L., Kellihan, H.B., Nguyenba, T.P., Lehmkuhl, L.B., Lefbom, B.K., Moise, N.S., & Hogan, D.F. (2009). Utility of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) to distinguish between congestive heart failure and non-cardiac causes of acute dyspnea in cats. J. Vet. Cardiol., 11, S51–S61. https://doi.org/10.1016/j.jvc.2008.12.001. CR - French, A. (2010). BSAVA Manual of Canine and Feline Cardiorespiratory Medicine (2nd ed.). Quedgeley: Br. Small Anim Vet. Assoc, 24: 213-219. CR - Gavazza, A., Marchegiani, A., Guerriero, L., Turinelli, V., Spaterna, A., Mangiaterra, S., Galosi, L., Rossi, G., & Cerquetella, M. (2021). Updates on Laboratory Evaluation of Feline Cardiac Diseases. Vet. Sci. 8(3), 41. https://doi.org/10.3390/VETSCI8030041. CR - Hall, D.J., Shofer, F., Meier, C.K., & Sleeper, M.M. (2007). Pericardial Effusion in Cats: A Retrospective Study of Clinical Findings and Outcome in 146 Cats. J. Vet. Intern. Med, 21(5), 1002–1007. https://doi.org/10.1111/J.1939-1676.2007.TB03056.X. CR - Hsu, A., Kittleson, M. D., & Paling, A. (2009). Investigation into the use of plasma NT-proBNP concentration to screen for feline hypertrophic cardiomyopathy. J. Vet. Cardiol, 11(SUPPL. 1), S63–S70. https://doi.org/10.1016/J.JVC.2009.02.005. CR - Krüger, M.U., Wünschmann, A., Ward, C., & Stauthammer, C.D. (2016). Pulmonary atresia with intact ventricular septum and hypoplastic right ventricle in an Arabian foal. J. Vet. Cardiol, 18(3), 284–289. https://doi.org/10.1016/j.jvc.2016.04.002. CR - Linney, C.J., Dukes-Mcewan, J., & Stephenson H.M., (2014). Left atrial size, atrial function and left ventricular diastolic function in cats with hypertrophic cardiomyopathy. J Small Anim Pract 55: 198–206. CR - Little, W.C., & Freeman, G.L. (2006). Pericardial Disease. Circulation, 113(12), 1622–1632. https://doi.org/10.1161/circulationaha.105.561514. CR - Machen, M.C., Oyama, M.A., Gordon, S.G., Rush, J.E., Achen, S.E., Stepien, R.L., Fox, P.R., Saunders, A.B., Cunningham, S.M., Lee, P.M., & Kellihan, H.B. (2014). Multi-centered investigation of a point-of-care NT-proBNP ELISA assay to detect moderate to severe occult (pre-clinical) feline heart disease in cats referred for cardiac evaluation. J. Vet. Cardiol, 16(4), 245–255. https://doi.org/10.1016/j.jvc.2014.09.002 CR - Owens, J.M. (1977). Pericardial effusion in the cat. Vet. Clin. North Am: Small Anim. Pract, 7, 373-383. CR - Palerme, J.S., Jones, A.E., Ward, J.L., Balakrishnan, N., Linder, K.E., Breitschwerdt, E.B., & Keene, B.W. (2016). Infective endocarditis in 13 cats. J. Vet. Cardiol, 18(3), 213–225. https://doi.org/10.1016/j.jvc.2016.04.003 CR - Perez, C., Hummel, J.B., Keene, B.W., Maggi, R.G., Diniz, P.P.V.P., & Breitschwerdt, E. B. (2010). Successful treatment of Bartonella henselae endocarditis in a cat. J. Feline Med.Surg, 12(6), 483–486. https://doi.org/10.1016/j.jfms.2009.12.018 CR - Stokol, T., Brooks, M., Rush, J.E., Rishniw, M., Erb, H., Rozanski, E., Kraus, M.S., & Gelzer, A.R. (2008). Hypercoagulability in cats with cardiomyopathy. J. Vet. Intern. Med., 22, 546–552. CR - Sykes, J.E., Kittleson, M.D., Chomel, B.B., MacDonald, K.A., & Pesavento, P. A. (2006). Clinicopathologic findings and outcome in dogs with infective endocarditis: 71 cases (1992–2005). J. Am. Vet. Med. Assoc, 228(11), 1735–1747. CR - Tilley, L.P., Owens, J.M., Wilkins, R.J., & Patnaik, A. K.. (1975). Pericardial mesothelioma effusion in a cat. J.Am. Anim. Hospt. Assoc, 11, 60-65. CR - Turgut, K. (2017). Klinik Kedi ve Köpek Kardiyolojisi; Nobel Tıp Kitabevleri: İstanbul, Turkey. CR - Ward, J.L., Lisciandro, G.R., Ware, W.A., Viall, A.K., Aona, B.D., Kurtz, K.A., Reina‐Doreste, Y., & DeFrancesco, T.C. (2018). Evaluation of point‐of‐care thoracic ultrasound and NT‐proBNP for the diagnosis of congestive heart failure in cats with respiratory distress. J. Vet. Intern. Med, 32(5), 1530–1540. https://doi.org/10.1111/jvim.15246 CR - Ware, W.A. (2011). Cardiovascular disease in small animal medicine. 3rd Edition. London: Manson publising, 22: 320- 337. CR - Yousaf, M., İilahi, M., Bibi, A., Elhassan, H., Sharif, M., Abid, A.R., Omran, M.A., Hassan, A., & Haroon, K.H. (2023). Chronic anemia complicated by cardiac failure, pulmonary hypertension, and pericardial effusion: a case report. J. Med. Case Rep, 17:44. https://doi.org/10.1186/s13256-022-03686-z UR - https://doi.org/10.24998/maeusabed.1610651 L1 - https://dergipark.org.tr/en/download/article-file/4481593 ER -