@article{article_1611164, title={Investigations of insulin resistance in obese dogs}, journal={Mediterranean Veterinary Journal}, volume={9}, pages={364–370}, year={2024}, DOI={10.24880/meditvetj.1611164}, author={Sarikaya, Ecenur Esra and Gökçe, Halil İbrahim}, keywords={Dog, insulin resistance, obese, overwight}, abstract={The aim of the study was to investigate insulin resistance in overweight and obese dogs. Obesity is excessive fat accumulation in the body and is defined as being 30% above the ideal body weight. In the study, a total of 30 dogs were divided into 3 equal groups: ideal weight, overweight and obese. Fasting serum samples were collected and used to measure insulin (INS) and asprosin (ASP) levels using dog-specific ELISA kits. Glucose (GLU) and fructosamine (FRU) were also determined using biochemistry analyzer and Idexx test kits, respectively. HOMA-IR (homeostasis model assessment of insulin resistance), HOMA-β% (homeostasis model assessment of β cell function) and insulin-glucose ratio (IGR) were calculated using glucose and insulin values. In the study, ASP (p <0.05), INS (p <0.05), HOMA-β (p <0.05) and IGR (p <0.05) values of both overweight and obese dogs were higher than the ideal weight group. Very strong correlations were detected between INS and HOMA-IR (p <0.01), HOMA-β (p <0.01), IGR (p <0.01) in both groups. It was determined that insulin resistance developed in 60% of overweight dogs and 90% of obese dogs. It is thought that HOMA-IR, HOMA-β, IGR, INS, FRU and ASP can be used in the evaluation of insulin resistance in obese dogs.}, number={3}, publisher={Burdur Mehmet Akif Ersoy University}