@article{article_1617126, title={Are NMDA Antagonists or Venlafaxine More Effective in the Forced Swimming Test?}, journal={Harran Üniversitesi Tıp Fakültesi Dergisi}, volume={22}, pages={233–238}, year={2025}, DOI={10.35440/hutfd.1617126}, author={İnal, Ahmet and Erenmemişoğlu, Aydın}, keywords={Amantadine, Folic acid, Depression, NMDA, Zinc, venlafaxine}, abstract={Background: The aim of this study is to compare the antidepressant-like effects of NMDA anta-gonists (zinc sulfate, amantadine, and folic acid) with venlafaxine.
Materials and Methods: Ninety-six male Swiss Albino mice were used in the experiments and divided into experimental groups. To assess depression-like behaviors in the animals, the forced swim test was performed. The effects of the drugs on locomotor activity were measured using the open field test.
Results: No differences were found between venlafaxine, folic acid, or zinc sulfate when admi-nistered alone in the experimental depression model. When administered in combination, the highest antidepressant-like effect was observed in the zinc-amantadine combination and the zinc sulfate-amantadine-folic acid combination. When venlafaxine and folic acid were adminis-tered together, the antidepressant-like effect was greater compared to other venlafaxine com-binations.
Conclusions: The use of these combinations in the treatment of depression is important for the enhancement of antidepressant efficacy.}, number={2}, publisher={Harran University}, organization={The Scientific Research Projects Unit of Erciyes University}