TY - JOUR T1 - Cognitive dysfunction after ischemic stroke AU - Ozdogru, Derya AU - Erdem, Miray PY - 2025 DA - March Y2 - 2025 DO - 10.18621/eurj.1618895 JF - The European Research Journal JO - Eur Res J PB - Prusa Medical Publishing WT - DergiPark SN - 2149-3189 SP - 420 EP - 426 VL - 11 IS - 2 LA - en AB - Objectives: One of the most important and common consequences of ischemic stroke is the cognitive impairment observed after stroke. This study aimed to investigate the role of strategic stroke among post-stroke cognitive impairment using the Montreal Cognitive Assessment Scale (MOCA). Methods: This study was planned as a prospective cross-sectional study. Patients admitted between 3 and 12 months after stroke were included in the study. Patients who had a stroke at least 3 months ago, who had not been admitted for a year after the stroke, and who gave consent to participate in the study were considered as inclusion criteria. Results: This study included 45 (44.1%) females and 57 (55.9%) males. When evaluated in terms of comorbidity, the frequency of hyperlipidemia was found to be significantly higher in the cognitively impaired group (46.5% vs. 25.4%, P=0.027). Thyroid stimulating hormone (TSH) levels were found to be lower in the Cognitive Impairment Group (0.93 μIU/mL vs. 1.03 μIU/mL, P=0.021). Considering the finding rates and significance level of lesion sites between the groups, the strategic infarction rate was found to be significantly higher in the cognitively impaired group (62.8% vs. 33.9%, P=0.004). In cognitive tests, the cognitive impairment group showed significantly lower performance in all areas (P<0.05). Conclusions: It should be kept in mind that the MOCA scale can be a good evaluation scale in detecting patients with cognitive impairment after ischemic stroke. KW - Montreal Cognitive Assessment Scale KW - Ischemic stroke KW - hyperlipidemia KW - cognitive impairment CR - 1. Pollock A, St George B, Fenton M, Firkins L. Top ten research priorities relating to life after stroke. Lancet Neurol. 2012;11(3):209. doi: 10.1016/S1474-4422(12)70029-7. CR - 2. Pendlebury ST, Rothwell PM; Oxford Vascular Study. Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study. Lancet Neurol. 2019;18(3):248-258. doi: 10.1016/S1474-4422(18)30442-3. CR - 3. Barbay M, Taillia H, Nédélec-Ciceri C, et al. Prevalence of Poststroke Neurocognitive Disorders Using National Institute of Neurological Disorders and Stroke-Canadian Stroke Network, VASCOG Criteria (Vascular Behavioral and Cognitive Disorders), and Optimized Criteria of Cognitive Deficit. Stroke. 2018;49(5):1141-1147. doi: 10.1161/STROKEAHA.117.018889. CR - 4. Pendlebury ST, Rothwell PM. Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis. Lancet Neurol. 2009;8(11):1006-1018. doi: 10.1016/S1474-4422(09)70236-4. CR - 5. Rost NS, Brodtmann A, Pase MP, et al. Post-Stroke Cognitive Impairment and Dementia. Circ Res. 2022;130(8):1252-1271. doi: 10.1161/CIRCRESAHA.122.319951. CR - 6. Aam S, Einstad MS, Munthe-Kaas R, et al. Post-stroke Cognitive Impairment-Impact of Follow-Up Time and Stroke Subtype on Severity and Cognitive Profile: The Nor-COAST Study. Front Neurol. 2020;11:699. doi: 10.3389/fneur.2020.00699. CR - 7. Biesbroek JM, Weaver NA, Biessels GJ. Lesion location and cognitive impact of cerebral small vessel disease. Clin Sci (Lond). 2017;131(8):715-728. doi: 10.1042/CS20160452. CR - 8. Karnath HO, Rennig J. Investigating structure and function in the healthy human brain: validity of acute versus chronic lesion-symptom mapping. Brain Struct Funct. 2017;222(5):2059-2070. doi: 10.1007/s00429-016-1325-7. CR - 9. Barbay M, Taillia H, Nédélec-Ciceri C, et al. Prevalence of Poststroke Neurocognitive Disorders Using National Institute of Neurological Disorders and Stroke-Canadian Stroke Network, VASCOG Criteria (Vascular Behavioral and Cognitive Disorders), and Optimized Criteria of Cognitive Deficit. Stroke. 2018;49(5):1141-1147. doi: 10.1161/STROKEAHA.117.018889. CR - 10. Munsch F, Sagnier S, Asselineau J, et al. Stroke Location Is an Independent Predictor of Cognitive Outcome. Stroke. 2016;47(1):66-73. doi: 10.1161/STROKEAHA.115.011242. CR - 11. Weaver NA, Kuijf HJ, Aben HP, et al. Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts. Lancet Neurol. 2021;20(6):448-459. doi: 10.1016/S1474-4422(21)00060-0. CR - 12. Weaver NA, Zhao L, Biesbroek JM, et al. The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study. Alzheimers Dement (Amst). 2019;11:310-326. doi: 10.1016/j.dadm.2019.02.007. CR - 13. Karnath HO, Sperber C, Rorden C. Mapping human brain lesions and their functional consequences. Neuroimage. 2018;165:180-189. doi: 10.1016/j.neuroimage.2017.10.028. CR - 14. Howard VJ, Cushman M, Pulley L, et al. The reasons for geographic and racial differences in stroke study: objectives and design. Neuroepidemiology. 2005;25(3):135-143. doi: 10.1159/000086678. CR - 15. Jayaraj RL, Azimullah S, Beiram R, Jalal FY, Rosenberg GA. Neuroinflammation: friend and foe for ischemic stroke. J Neuroinflammation. 2019;16(1):142. doi: 10.1186/s12974-019-1516-2. CR - 16. Rodondi N, den Elzen WP, Bauer DC, et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA. 2010;304(12):1365-1374. doi: 10.1001/jama.2010.1361. CR - 17. Collet TH, Gussekloo J, Bauer DC, et al. Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. Arch Intern Med. 2012;172(10):799-809. doi: 10.1001/archinternmed.2012.402. CR - 18. Feigin VL, Forouzanfar MH, Krishnamurthi R, et al. Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010. Lancet. 2014;383(9913):245-254. doi: 10.1016/s0140-6736(13)61953-4. CR - 19. Selmer C, Olesen JB, Hansen ML, et al. The spectrum of thyroid disease and risk of new onset atrial fibrillation: a large population cohort study. BMJ. 2012;345:e7895. doi: 10.1136/bmj.e7895. UR - https://doi.org/10.18621/eurj.1618895 L1 - https://dergipark.org.tr/en/download/article-file/4516783 ER -