@article{article_1620976, title={The relationship between endothelial activation and stress index with survival and early mortality in acute myeloid leukemia}, journal={Ege Tıp Dergisi}, volume={64}, pages={606–611}, year={2025}, DOI={10.19161/etd.1620976}, url={https://izlik.org/JA98UE36WC}, author={Demirci, Ufuk and Umit, Elif and Aslan, Erge and Alp Kırkızlar, Tuğcan and Kırkızlar, Hakkı Onur and Demir, Ahmet Muzaffer}, keywords={Endothelial dysfunction, Acute myeloid leukemia, Early mortality}, abstract={Aim: The Endothelial Activation and Stress Index (EASIX) score is used as a marker of endothelial damage and used to predict acute graft-versus-host disease and sinusoidal obstruction syndrome. We wanted to evaluate the effects of EASIX, modified EASIX (mEASIX) and sepsis modified EASIX (sEASIX) on early mortality and overall survival (OS) in patients with acute myeloid leukemia. Materials and Methods: We reviewed patients diagnosed and followed up with Acute Myeloid Leukemia (AML) in our Hematology Department, retrospectively. Patients between 18 -70 years of age and who were administered 7+3 (7 days cytarabine, and 3 days anthracycline) chemotherapy protocol (except acute promyelocytic leukemia) were included. EASIX, mEASIX and sEASIX scores of the patients, both at the time of diagnosis and at the end of the 4th week, were calculated. Results: Seventy-five patients were included in the study. The mean age was 49.05 (19-68) years and 41% were alive. EASIX and mEASIX scores measured both at the time of diagnosis and at the end of induction therapy were found to be significantly associated with early mortality (p=0.01, p <0.01) and OS (p <0.01, p <0.01). Conclusion: There is no specific scoring system or marker that we can use practically in the clinic to show early mortality in these patients who receive intensive treatment in AML. Of course, there are many factors that can affect mortality in this period. However, based on the current results, we think that EASIX, mEASIX and sEASIX scores can be used with other prognostic factors to predict early mortality and survival.}, number={4}